AI Article Synopsis
- The study compares the effectiveness of tobramycin-containing bone cement versus systemic cefazolin in treating infections during a one-stage revision surgery in rabbits.
- Results showed both antibiotic treatments significantly reduced bacterial counts compared to controls, but systemic cefazolin demonstrated slightly better infection rates.
- The persistence of bacterial DNA post-treatment suggests it might be due to slow DNA clearance rather than ongoing infection, indicating a potential benefit in combining both types of antibiotics for optimal treatment.
Article Abstract
The efficacy of tobramycin-containing bone cement with that of systemic cefazolin for treatment of infection in a one-stage revision model is compared. In addition, the value of detecting bacterial DNA after antibiotic treatment was investigated. An implant was inserted into the right tibia of rabbits after inoculation with Staphylococcus aureus. At 28 days, the implant was removed. Subsequently, either plain bone cement with or without systemic administration of cefazolin, or tobramycin-containing bone cement was injected into the medullary canal. The tibiae were cultured 14 days after revision (Day 42), and showed a significant decrease in bacterial counts for both antibiotic groups compared with the control group (p
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| http://dx.doi.org/10.1002/jbm.1073 | DOI Listing |
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