There are four members of the platelet-derived growth factor (PDGF) family; PDGF-A, PDGF-B, PDGF-C and PDGF-D. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-alpha and PDGFR-beta, and PDGF-mediated signaling is critical for development of many organ systems. Analysis in adult tissues showed that PDGF-C was mainly expressed in kidney, testis, liver, heart and brain. During development, PDGF-C expression was widespread and dynamic, and found in somites and their derivatives, in kidney, lung, brain, and in several other tissues, particularly at sites of developing epidermal openings. PDGF-C may therefore have unique functions during tissue development and maintenance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0925-4773(01)00560-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeting PDGF-CC as a promising therapeutic strategy to inhibit cholangiocarcinoma progression.
J Transl Med
November 2024
Department of Hepatobiliary surgery, the Third Affiliated Hospital of Southern Medical University, 183 Zhongshan Avenue West, Tianhe District, Guangzhou, 510630, Guangdong, China.
Article Synopsis
- Cholangiocarcinoma (CCA) is a severe cancer with few treatment options, and the study focuses on the role of Platelet-Derived Growth Factor CC (PDGF-CC) in its progression.
- Researchers compared PDGF-CC levels in CCA and normal tissues and found elevated mRNA and protein levels in CCA, linking high PDGF-CC expression to worse survival rates for patients.
- By depleting PDGF-CC in various cell lines and using xenograft models, the study demonstrated that reducing PDGF-CC leads to decreased cancer cell growth and suggests that targeting PDGF-CC could be a promising therapeutic approach for CCA.
Roles of PDGF/PDGFR signaling in various organs.
Korean J Physiol Pharmacol
October 2024
Department of Physiology, College of Medicine, Jeju National University, Jeju 63243, Korea.
Platelet-derived growth factors (PDGFs) ligands and their corresponding receptors, PDGF receptor (PDGFR)α and PDGFRβ, play a crucial role in controlling diverse biological functions, including cell growth, viability and migration. These growth factors bind to PDGFRs, which are receptor tyrosine kinases present on the surface of target cells. The interaction between PDGFs and PDGFRs induces receptor dimerization and subsequent activation through auto-phosphorylation, which in turn triggers a cascade of intracellular signaling pathways.
View Article and Find Full Text PDFPlatelet-Derived Growth Factor C Facilitates Malignant Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated Lipid Metabolism.
Adv Sci (Weinh)
October 2024
Department of Pancreato-Biliary Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Lipid metabolism reprogramming stands as a fundamental hallmark of cancer cells. Unraveling the core regulators of lipid biosynthesis holds the potential to find promising therapeutic targets in pancreatic ductal adenocarcinoma (PDAC). Here, it is demonstrated that platelet-derived growth factor C (PDGFC) orchestrated lipid metabolism, thereby facilitated the malignant progression of PDAC.
View Article and Find Full Text PDFHypoxia-inducible factor 1alpha and vascular endothelial growth factor in Glioblastoma Multiforme: a systematic review going beyond pathologic implications.
Oncol Res
July 2024
Department of Pathology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, 41500, Greece.
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor characterized by extensive heterogeneity and vascular proliferation. Hypoxic conditions in the tissue microenvironment are considered a pivotal player leading tumor progression. Specifically, hypoxia is known to activate inducible factors, such as hypoxia-inducible factor 1alpha (HIF-1α), which in turn can stimulate tumor neo-angiogenesis through activation of various downward mediators, such as the vascular endothelial growth factor (VEGF).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!