Purpose: We assessed the psychometric properties of the newly developed Erectile Dysfunction Effect on Quality of Life (ED-EQoL) instrument for quantifying the effect of erectile dysfunction on quality of life.
Materials And Methods: The questionnaire was assessed in a cohort of 283 men recruited from 11 centers in the United Kingdom. Internal consistency was examined by Cronbach's alpha, test-retest reliability was determined by administering the instrument on 2 occasions 2 weeks apart without treatment in the interim, construct validity was assessed by comparison with other quality of life measures and responsiveness was evaluated by comparing the change in the ED-EQoL after treatment with change in other measures.
Results: The ED-EQoL was simple to complete and captured wide variation in quality of life. It demonstrated good internal consistency and reliability, and generally correlated in an expected manner with other quality of life measures. Correlation with initial erectile function was relatively low but the change in function after treatment was reflected by the change in quality of life.
Conclusions: When assessing erectile dysfunction in clinical practice or research, it is important to consider the effect on quality of life in addition to function. To our knowledge the ED-EQoL is the first erectile dysfunction specific quality of life instrument developed and extensively validated according to accepted principles of questionnaire design. Combined with a measure of erectile function its use is recommended in routine clinical practice and in research to provide a holistic approach to the assessment of erectile dysfunction and its treatment.
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JAMA
January 2025
Worcestershire Royal Hospital, Worcester, United Kingdom.
Importance: Patients undergoing unplanned abdominal surgical procedures are at increased risk of surgical site infection (SSI). It is not known if incisional negative pressure wound therapy (iNPWT) can reduce SSI rates in this setting.
Objective: To evaluate the effectiveness of iNPWT in reducing the rate of SSI in adults undergoing emergency laparotomy with primary skin closure.
JAMA Pediatr
January 2025
Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Importance: Cyclophosphamide and calcineurin inhibitors are the most used nonsteroid immunosuppressive medications globally for children with various chronic inflammatory conditions. Their comparative effectiveness remains uncertain, leading to worldwide practice variation. Nephrotic syndrome is the most common kidney disease managed by pediatricians globally and suboptimal treatment is associated with high morbidity.
View Article and Find Full Text PDFPlant Foods Hum Nutr
January 2025
College of Food Science and Engineering, Ningbo University, Ningbo, 315832, PR China.
Quinoa polysaccharides have attracted significant research interest in recent years due to their diverse biological activities, including antiviral, anti-inflammatory, antioxidant, and immunoregulatory properties. These attributes align with the growing global demand for natural, functional food ingredients, positioning quinoa polysaccharides as a valuable resource in food science and technology. This review presents an overview of the various bioactivities of quinoa polysaccharides, critically evaluates the methods used for their extraction and purification, describes their structural characteristics, and discusses their practical applications across multiple areas within the food industry, including food additives, meat products, health foods, and innovative food packaging.
View Article and Find Full Text PDFJ Youth Adolesc
January 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Adolescence is a vulnerable period for the onset of mental disorders and risk behaviours. Based on the Health-Promoting Schools Framework, whole-school interventions offer a promising strategy in this developmentally-sensitive cohort, through championing a systems-based approach to promotion and prevention that involves the key stakeholders in an adolescent's life. The evidence-base surrounding the effectiveness of whole-school interventions, however, remains inconclusive, partly due to the insufficient number of studies in previous meta-analyses.
View Article and Find Full Text PDFCurr Rheumatol Rep
January 2025
Rheumatologisches Versorgungszentrum Steglitz, Ruhr Universität Bochum, Schloßstr.110, 12163, Berlin, Germany.
Purpose Of Review: Axial spondyloarthritis (axSpA) is a rather prevalent chronic inflammatory rheumatic disease that affects already relatively young patients. It has been known better since the end of the nineteenth century but quite a lot has been learned since the early 60ies when the first classification (diagnostic) criteria for ankylosing spondylitis (AS) were agreed on. I have been part of many developments in the last 30 years, and I'm happy to have been able to contribute to the scientific progress in terms of diagnosis, imaging, pathophysiology and therapy.
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