omega-(1H-Imidazol-4-yl)alkane-1-sulfonamides were prepared and found to be potent histamine H(3) receptor antagonists. High receptor affinity and a low difference in the data between the bioassays were achieved with 5-(1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide (16). Good in vitro profiles were also obtained for 2-hydroxysulfonamide and vinylsulfonamide analogues. This complements and completes the existing set of imidazole-based sulfonamides and sulfamides.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0968-0896(01)00295-4 | DOI Listing |
Publication Analysis
Top Keywords
potent histamine
8
histamine receptor
8
receptor antagonists
8
omega-imidazol-4-ylalkane-1-sulfonamides series
4
series potent
4
antagonists omega-1h-imidazol-4-ylalkane-1-sulfonamides
4
omega-1h-imidazol-4-ylalkane-1-sulfonamides prepared
4
prepared potent
4
antagonists high
4
high receptor
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!