Intravenous administration of 400-600 mg/day potassium canrenoate normalised plasma osmolarity and permitted rapid re-establishment of the metabolic picture in 9/12 patients with hyperosmolarity admitted to a resuscitation department for complex physiopathological pictures. The soundness of the drug in this sense is affirmed, as well as its permission of the recommencement of parenteral nutrition.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The Effect of Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic on the Metabolic Tumor Markers: A Real-World Retrospective Study.
Diabetes Metab Syndr Obes
November 2024
Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People's Republic of China.
Article Synopsis
- * Researchers analyzed data from 565 diabetic patients and found significantly higher levels of carbohydrate antigen 199 (CA199) in DKA and carcinoembryonic antigen (CEA) in HHS, alongside other clinical laboratory findings indicating altered metabolic and organ function.
- * The results suggest that elevated CA199 in DKA is linked to acidosis, while elevated CEA in HHS may relate to iron balance, with osmolarity identified as a key
Hypertonic saline achieves superior brain relaxation in tumor craniotomy: An updated systematic-network meta-analysis.
J Taibah Univ Med Sci
October 2024
Department of Anesthesiology and Intensive Therapy, Dr Hasan Sadikin Hospital - Padjadjaran University, Bandung, West Java, Indonesia.
Article Synopsis
- The study investigates the effectiveness and safety of hypertonic saline (HTS) compared to mannitol in reducing intracranial pressure (ICP) during brain tumor craniotomy in adults.
- A systematic review of eleven randomized controlled trials (RCTs) with 593 participants showed that HTS resulted in greater brain relaxation and lower urine output compared to mannitol, while also improving mean arterial pressure.
- While HTS was found to be superior in achieving brain relaxation, it did lead to higher plasma sodium levels, highlighting a trade-off in its usage during surgery.
Flow Cytometry as a New Accessible Method to Evaluate Diagnostic Osmotic Changes in Patients with Red Blood Cell Membrane Defects.
Biomedicines
July 2024
Instituto Murciano de Investigación Biosanitaria (IMIB)-Arrixaca, 30120 Murcia, Spain.
Hereditary spherocytosis (HS) is a membranopathy that impacts the vertical junctions between the cytoskeleton and the plasma membrane of erythrocytes. The gold standard method for diagnosing it is osmotic gradient ektacytometry (OGE). However, access to this technique is scarce.
View Article and Find Full Text PDFHyperosmolarity in children with hyperammonemia: a risk of brain herniation at the start of renal replacement therapy.
Front Pediatr
July 2024
Pediatric Intensive Care Unit, Department of Pediatrics CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada.
Article Synopsis
- The study examines the use of renal replacement therapy (RRT) to treat hyperammonemia in children, particularly focusing on its impact on plasma osmolarity and the risk of neurological issues.
- A total of 11 pediatric patients were analyzed, revealing a significant correlation between high ammonia levels and increased plasma osmolarity, with potential complications such as brain herniation occurring during rapid osmolar changes.
- The findings emphasize the importance of monitoring plasma osmolarity in young patients undergoing RRT to prevent serious neurological complications.
A Toluene-induced Infundibulo-neurohypophysitis: A New Cause of Hypophysitis Secondary to Toxic Exposure.
Endocr Metab Immune Disord Drug Targets
July 2024
Department of Endocrinology, Diabetology and Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Background: Hypophysitis is a rare inflammatory disorder of the pituitary gland. Symptoms and signs of hypophysitis can be various, and its recognition may be challenging. Arginine vasopressin deficiency (AVP-D) due to exposure to a variety of drugs and toxic substances is rare, but some cases have been reported.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!