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Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mice.
Brain Behav Immun Health
February 2025
Department of Physiology, School of Medicine, University College Cork, Western Road, Cork, Ireland.
Duchenne muscular dystrophy (DMD), an X-linked neuromuscular disorder, characterised by progressive immobility, chronic inflammation and premature death, is caused by the loss of the mechano-transducing signalling molecule, dystrophin. In non-contracting cells, such as neurons, dystrophin is likely to have a functional role in synaptic plasticity, anchoring post-synaptic receptors. Dystrophin-expressing hippocampal neurons are key to cognitive functions such as emotions, learning and the consolidation of memories.
View Article and Find Full Text PDFLactoferrin targeting INTL1 receptor inhibits hepatocellular carcinoma progression via apoptosis and cell cycle signaling pathways.
Sci Rep
December 2024
Department of Life Sciences, College of Life Sciences, National Chung Hsing University, Kuo Kuang Rd., Taichung, 402, Taiwan.
Hepatocellular carcinoma (HCC) constitutes 90% of liver cancer cases and ranks as the third leading cause of cancer-related mortality, necessitating urgent development of alternative therapies. Lactoferrin (LF), a natural iron-binding glycoprotein with reported anticancer effects, is investigated for its potential in liver cancer treatment, an area with limited existing studies. This study focuses on evaluating LF's anti-liver cancer effects on HCC cells and assessing the preventive efficacy of oral LF administration in a murine model.
View Article and Find Full Text PDFNimotuzumab and irinotecan synergistically induce ROS-mediated apoptosis by endoplasmic reticulum stress and mitochondrial-mediated pathway in cervical cancer.
Biotechnol Appl Biochem
December 2024
Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Article Synopsis
- Irinotecan (CPT-11) is a chemotherapy drug that can harm healthy cells while treating cancer, while Nimotuzumab (NmAb) is a monoclonal antibody that targets the epidermal growth factor receptor (EGFR) in cancers with EGFR overexpression.
- This study examines how the combination of CPT-11 and NmAb affects HeLa cervical cancer cells, finding that the combination leads to more cell death and apoptosis compared to either treatment alone.
- The combined treatment increases levels of reactive oxygen species and activates key proteins involved in cell stress and death, suggesting that NmAb enhances the cancer-fighting effects of CPT-11 and could improve treatment for cervical cancer in humans.
Valsartan: An Angiotensin Receptor Blocker Modulates BDNF Expression and Provides Neuroprotection Against Cerebral Ischemic Reperfusion Injury.
Mol Neurobiol
December 2024
Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, 110062, India.
AT1 receptor blockers (ARBs) are commonly used drugs to treat cardiovascular disease and hypertension, but research on their impact on brain disorders is unattainable. Valsartan (VAL) is a drug that specifically blocks AT1 receptor. Despite the previous evidence for VAL to provide neuroprotection in case of ischemic reperfusion injury, evaluation of their potential in mitigating mitochondrial dysfunction that causes neuronal cell death and neurobehavioral impairment remains unknown.
View Article and Find Full Text PDFMitochondrial damage and clearance in retinal pigment epithelial cells.
Acta Ophthalmol
March 2024
Department of Medicine, Clinical Medicine Unit, University of Eastern Finland Institute of Clinical Medicine, Kuopio, Northern Savonia, Finland.
Article Synopsis
- * The study developed a double-knockout mouse model to mimic AMD characteristics, revealing issues with the cellular clearance systems in retinal cells.
- * Findings showed disrupted autophagy in the RPE cells, indicating problems in clearing damaged mitochondria, despite increased markers for autophagy and mitophagy.
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