Phocid herpesvirus type 1 (PhHV-1) causes significant morbidity and mortality among young and immunocompromised harbour seals. Therefore, the availability of an effective PhHV-1 vaccine would be of importance for orphanages and seal rehabilitation centres. Since possibilities to test PhHV-1 candidate vaccines in the target species are limited, a suitable animal model is needed. Given the close genetic and antigenic relationships between PhHV-1 and feline herpesvirus (FHV), the FHV cat system could be considered to test candidate PhHV-1 vaccines. Here we have tested a PhHV-1 based ISCOM vaccine for its protective efficacy against FHV infection in cats. To this end, three groups of cats were vaccinated thrice with ISCOM adjuvanted PhHV-1, FHV, and mock vaccines, respectively. One month after the last vaccination, all cats were challenged with a virulent FHV strain. All PhHV-1 and FHV vaccinated cats were protected from developing severe disease and excreted significantly less FHV than the mock vaccinated cats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0264-410x(01)00378-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
CAUSES AND TRENDS OF HARBOR SEAL (PHOCA VITULINA) MORTALITY ALONG THE BRITISH COLUMBIA COAST, CANADA, 2012-2020.
J Wildl Dis
October 2023
Animal Health Center British Columbia Ministry of Agriculture, 1767 Angus Campbell Rd., Abbotsford, British Columbia V3G 2M3, Canada.
A retrospective study was conducted to categorize and describe the causes of mortality in harbor seals (Phoca vitulina) along the British Columbia coast that presented to the Vancouver Aquarium Marine Mammal Rescue Centre (MMR) for rehabilitation from 2012 to 2020. Medical records for 1,279 predominantly perinatal live-stranded harbor seals recovered in this region were reviewed. Approximately 20.
View Article and Find Full Text PDFNovel herpesvirus discovered in walrus liver.
Virus Genes
April 2021
Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Article Synopsis
- A walrus born in an aquarium in Japan died at 11 months due to symptoms like fever and poor appetite, which were linked to liver and adrenal gland damage.
- Necropsy and histological examinations revealed necrotic lesions and the presence of a new virus named Walrus alphaherpesvirus 1 (WaHV-1), closely related to viruses found in harbor seals.
- The mother walrus showed past herpesvirus infection, suggesting that the young walrus may have contracted WaHV-1 from her and did not receive the necessary maternal antibodies to combat the virus.
Widespread neonatal infection with phocid herpesvirus 1 in free-ranging and stranded grey seals Halichoerus grypus.
Dis Aquat Organ
March 2019
Moredun Research Institute, Edinburgh EH26 0PZ, UK.
Phocid herpesvirus 1 (PhHV-1) is known to infect grey seals Halichoerus grypus but little is known about its pathogenicity or true prevalence in this species. To investigate the prevalence of and risk factors associated with PHV-1 infection, nasal swabs were collected from grey seal pups and yearlings on the Isle of May, a well-studied grey seal breeding colony, and from stranded grey seal pups submitted to a rehabilitation centre. PhHV-1 nucleic acids were detected in nasal swabs from 58% (52/90) of live free-ranging grey seal pups, 62% (18/29) of live stranded grey seal pups and 28% (5/18) of live free-ranging yearlings, suggesting recrudescence in the latter.
View Article and Find Full Text PDFHERPESVIRUSES INCLUDING NOVEL GAMMAHERPESVIRUSES ARE WIDESPREAD AMONG PHOCID SEAL SPECIES IN CANADA.
J Wildl Dis
January 2016
1 The Swine and Poultry Infectious Diseases Research Center (CRIPA), Faculté de Médecine Vétérinaire, Université de Montréal, 3200 rue Sicotte, St-Hyacinthe, Québec J2S 7C6, Canada.
Little is known about herpesviruses in Canadian pinnipeds. We measured prevalence of antibodies to herpesviruses in the sera from Canadian phocid seals by an indirect enzyme-linked immunosorbent assay. Wild harbor seals (Phoca vitulina) and captive harbor seals were positive for antibodies to Phocid herpesvirus 1 (PhoHV-1) at prevalences of 91% and 100%, respectively.
View Article and Find Full Text PDFIntroduction: Biological samples, pharmaceuticals or food contain proteins, lipids, polymers, ammoniums and macromolecules that alter the detection of infectious agents by DNA amplification techniques (PCR). Moreover the targeted DNA has to be released from the complex cell walls and the compact nucleoprotein matrixes and cleared from potential inhibitors. The goal of the present work was to assess the efficiency of enzymatic pretreatments on infectious agents to make DNA available for further extraction and amplification.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!