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Disaccharidase Enzyme Deficiency in Adult Patients with Gas and Bloating.
Clin Transl Gastroenterol
January 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Wellstar Medical College of Georgia, Augusta University, Augusta, Georgia.
Introduction: Disaccharidases produced by the small intestinal brush border facilitate digestion of dietary carbohydrates. If deficient, they can cause carbohydrate malabsorption resulting in several abdominal symptoms. Our aim was to examine the prevalence of disaccharidase deficiency and correlate this with abdominal symptoms in adult patients with chronic abdominal symptoms.
View Article and Find Full Text PDFOlfactory cleft brushing: A minimally invasive tool for biomarker analysis in rhinology.
Am J Otolaryngol
December 2024
Department of Otorhinolaryngology, University of Rome Tor Vergata, Rome 00133, Italy.
Introduction: Olfactory dysfunction is a prevalent condition associated with post-viral syndromes, chronic rhinosinusitis, and neurodegenerative diseases. While olfactory cleft sampling has been investigated in neurology, its potential for assessing localized biomarkers in rhinological conditions remains underexplored. This study presents a minimally invasive nasal brushing technique specifically targeting the olfactory cleft, enabling simultaneous biomarker quantification and cytological analysis.
View Article and Find Full Text PDFEffectiveness of cholangioscopy guided biopsy versus ERCP guided brushings in diagnosing malignant biliary strictures.
Surg Endosc
December 2024
University of South Carolina School of Medicine Greenville, Greenville, SC, USA.
Background: Evaluation of lesions of the biliary tract are essential to diagnose given the dismal outcomes of cholangiocarcinoma. Historically, these diagnoses were made using brush biopsies obtained under Endoscopic Retrograde Cholangiopancreatography (ERCP). To increase the accuracy of biliary biopsies, SpyGlassTM Discover cholangioscopy guided biopsy has been developed, providing greater tissue yield and direct visualization of the biliary epithelium.
View Article and Find Full Text PDFDiagnostic work-up of bile duct strictures: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Endoscopy
December 2024
Hepatogastroenterology Unit, 2nd Department of Internal Medicine, Propaedeutic, Medical School, National and Kapodistrian University of Athens, "Attikon" University General Hospital, Athens, Greece.
1: ESGE recommends the combination of endoscopic ultrasound-guided tissue acquisition (EUS-TA) and endoscopic retrograde cholangiopancreatography (ERCP)-based tissue acquisition as the preferred diagnostic approach for tissue acquisition in patients with jaundice and distal extrahepatic biliary stricture in the absence of a pancreatic mass. 2: ESGE suggests that brushing cytology should be completed along with fluoroscopy-guided biopsies, wherever technically feasible, in patients with perihilar biliary strictures. 3: ESGE suggests EUS-TA for perihilar strictures when ERCP-based modalities yield insufficient results, provided that curative resection is not feasible and/or when cross-sectional imaging has shown accessible extraluminal disease.
View Article and Find Full Text PDFReversible Lubricating Layer for Improving the Endoscope Field with High Transparency and Antipollution Property.
ACS Appl Mater Interfaces
January 2025
School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Endoscopes, a minimally invasive medical tool, are susceptible to impaired visibility due to the adhesion of biological fluids. However, traditional self-cleaning coatings face limitations in terms of transparency and sustainability, making it difficult to apply them to lenses. Inspired by the phospholipid layer of the eye, a reversible lubricating layer (RL-layer) with low-adhesion and high-transparency properties is reported.
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