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Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside.
J Biochem
May 2024
Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
The rapid emergence of multi-drug-resistant bacteria has raised a serious public health concern. Therefore, new antibiotic developments have been highly desired. Here, we propose a new method to visualize antibiotic actions on translating ribosomes in the cell-free system under macromolecular crowding conditions by cryo-electron microscopy, designated as the DARC method: the Direct visualization of Antibiotic binding on Ribosomes in the Cell-free translation system.
View Article and Find Full Text PDFAnalysis of impurity profiling of arbekacin sulfate by ion-pair liquid chromatography coupled with pulsed electrochemical detection and online ion suppressor-ion trap-time off light mass spectrometry.
J Pharm Biomed Anal
November 2022
NMPA Key Laboratory for Impurity Profile of Chemical Drugs, Nanjing 210019, China; Jiangsu Institute for Food and Drug Control, Nanjing 210019, China; Nanjing Normal University, College of Food and Pharmaceutical Engineering, Nanjing 210023, China. Electronic address:
Ion-pair liquid chromatography with pulsed electrochemical detection (LC-PED) was established for the analysis of impurities in arbekacin (ABK) sulfate. APursuit pentafluorophenylpropyl (PFP) column was used as stationary phase. This novel method showed greater separation and sensitivity ability.
View Article and Find Full Text PDFStenotrophomonas maltophilia from Nepal Producing Two Novel Antibiotic Inactivating Enzymes, a Class A β-Lactamase KBL-1 and an Aminoglycoside 6'--Acetyltransferase AAC(6')-Iap.
Microbiol Spectr
August 2022
Department of Microbiology, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
Seven drug-resistant strains of Stenotrophomonas maltophilia were isolated from patients at two university hospitals in Nepal. S. maltophilia JUNP497 was found to encode a novel class A β-lactamase, KBL-1 (Kathmandu β-lactamase), consisting of 286 amino acids with 52.
View Article and Find Full Text PDFA study of trends and factors associated with therapeutic drug monitoring (TDM) implementation for arbekacin treatment using a large Japanese medical claims database.
J Infect Chemother
September 2022
Department of Clinical Pharmacoepidemiology, Kyoto Pharmaceutical University; 5 Misasagi-nakauchi-cho, Yamashina-ku, Kyoto, 607-8414, Japan. Electronic address:
Introduction: Reimbursements for pharmacist interventions and infectious disease teams have recently been introduced in Japan. Arbekacin (ABK) is used to treat pneumonia and sepsis caused by methicillin-resistant Staphylococcus aureus, and therapeutic drug monitoring (TDM) is recommended. This study aimed to clarify the trend in TDM implementation for ABK over time and the factors associated with TDM implementation using a claims database.
View Article and Find Full Text PDFMechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin.
Nucleic Acids Res
July 2021
Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden.
How aminoglycoside antibiotics limit bacterial growth and viability is not clearly understood. Here we employ fast kinetics to reveal the molecular mechanism of action of a clinically used, new-generation, semisynthetic aminoglycoside Arbekacin (ABK), which is designed to avoid enzyme-mediated deactivation common to other aminoglycosides. Our results portray complete picture of ABK inhibition of bacterial translation with precise quantitative characterizations.
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