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Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation.
Sci Adv
January 2025
Division of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Ketogenesis is a dynamic metabolic conduit supporting hepatic fat oxidation particularly when carbohydrates are in short supply. Ketone bodies may be recycled into anabolic substrates, but a physiological role for this process has not been identified. Here, we use mass spectrometry-based C-isotope tracing and shotgun lipidomics to establish a link between hepatic ketogenesis and lipid anabolism.
View Article and Find Full Text PDFBeyond virologic suppression.
AIDS
March 2025
Center of Excellence in Preventive and Integrative Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
The Impact of Mercury from Dental Amalgams on Pregnancy and Childhood: A Health and Risk Assessment Evaluation.
Curr Med Chem
January 2025
Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway.
Mercury is a pervasive global pollutant, with primary anthropogenic sources including mining, industrial processes, and mercury-containing products such as dental amalgams. These sources release mercury into the environment, where it accumulates in ecosystems and enters the food chain, notably through bioamplification in marine life, posing a risk to human health. Dental amalgams, widely used for over a century, serve as a significant endogenous source of inorganic mercury.
View Article and Find Full Text PDFSelect microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling.
iScience
February 2025
Department of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
The vagus nerve is proposed to enable communication between the gut microbiome and the brain, but activity-based evidence is lacking. We find that mice reared germ-free exhibit decreased vagal tone relative to colonized controls, which is reversed via microbiota restoration. Perfusing antibiotics into the small intestines of conventional mice, but not germ-free mice, acutely decreases vagal activity which is restored upon re-perfusion with intestinal filtrates from conventional, but not germ-free, mice.
View Article and Find Full Text PDFDissociable ventral and dorsal sensorimotor functional circuits linking the hypomanic personality traits to aggression via behavioral inhibition system.
Int J Clin Health Psychol
January 2025
Faculty of Psychology, Tianjin Normal University, Tianjin, 300387, China.
Article Synopsis
- Hypomanic personality traits (HPT) are linked to higher risk for psychiatric disorders like bipolar disorder and are associated with aggressive behaviors, yet the underlying neuropsychological mechanisms are not fully understood.
- The study used psychometric network analysis to identify key factors (Behavioral Inhibition System and mood volatility) that connect HPT to aggression, finding that mood volatility positively correlates with aggression, with BIS acting as a mediator.
- Further imaging studies revealed distinct functions of the dorsal and ventral sensorimotor cortices in processing rewards, and resting-state imaging confirmed these regions' connections to different brain networks, highlighting the importance of these circuits in mediating the relationship between mood volatility, aggression, and BIS.
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