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http://dx.doi.org/10.1086/324094DOI Listing

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Article Synopsis
  • The study examined how the severity and presentation of multisystem inflammatory syndrome in children (MIS-C) vary among different SARS-CoV-2 variants using a group of 59 patients aged 0-18 years diagnosed with COVID-19 and MIS-C over a year.
  • Results showed that most patients were diagnosed during the Alpha (41%) and Delta (32%) periods, and respiratory symptoms were notably common in the Delta variant group.
  • However, the study found no significant differences in overall symptoms, lab results, treatment, or long-term outcomes across the different variant groups.
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: Due to its link with the SARS-CoV-2, Multisystem Inflammatory Syndrome in Children (MIS-C) gained global attention as a serious condition that requires hospital care. Our study aimed to present the clinical and laboratory characteristics of MIS-C patients by age group and intensive care unit (ICU) admission status and assess early echocardiographic changes. : A single-center partly retrospective, partly prospective observational cohort study was performed from December 2020 to June 2024.

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Background: COVID-19 related syndromes are not yet well described and understood. Multisystem inflammatory syndrome of the adults (MIS-A) is a recently characterized syndrome affecting multiple organs of young adults, causing serious complications, even shock and death.

Objectives: To determine the clinical characteristics, course, and complications of MIS-A in a systematic way and summarize currently used treatments.

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The coronavirus disease 2019 (COVID-19) pandemic that was spread worldwide since 2019 and showed a highly contagious character affecting the lifestyle of people worldwide causing symptoms that are not limited to the respiratory system only but had multi-systemic effects that may progress to severe complications that roughly affect people's health. A newly recognized SARS-CoV-2-associated syndrome called pediatric multisystem inflammatory syndrome has been described worldwide. Initially, it was reported as hyper-inflammatory shock and "Kawasaki-like" symptoms with fever and conjunctivitis, a similar syndrome is also reported in neonates and called Multisystem Inflammatory Syndrome of neonates (MIS-N).

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Multisystem inflammatory syndrome in adults (MIS-A) is a systemic inflammatory disease associated with COVID-19 and follows coronary artery aneurysms similar to Kawasaki disease. In many cases, it is improved by treatments such as high-dose steroids or intravenous immunoglobulin (IVIg). However, the role of untreated coronary artery aneurysms leading to future stenosis remains unknown.

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