Mycobacterium avium complex (MAC) is a rare cause of isolated intrathoracic disease in the immunocompetent child; delays in diagnosis and treatment are common. The current case is an 11-month-old girl with symptoms, signs, and radiographic findings of bronchial obstruction. Comparison of this case to the literature revealed that there is a characteristic presentation of intrathoracic MAC infection in immunocompetent children (children aged 3 years or less, without exposure to Mycobacterium tuberculosis, presenting with clinical and radiographic evidence of bronchial obstruction) that should increase our index of suspicion for this diagnosis. This is particularly important since M. tuberculosis can present in a similar pattern.
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http://dx.doi.org/10.1007/s002470100003 | DOI Listing |
Cureus
November 2024
Acute Internal Medicine, The Royal Wolverhampton NHS Trust, Wolverhampton, GBR.
Intrathoracic meningocele is a condition characterized by the protrusion of dura mater and cerebrospinal fluid within the thoracic cavity. This can be associated with neurofibromatosis type 1 (NF1) and other connective tissue disorders. Less commonly, it can occur in isolation.
View Article and Find Full Text PDFGen Thorac Cardiovasc Surg Cases
November 2023
Division of Chest Surgery, Department of Surgery, Toho University School of Medicine, 6-11-1, Omorinishi, Ota, Tokyo, 143-8541, Japan.
Background: A unilateral absence of the pulmonary artery (UAPA) is a rare congenital anomaly, which in most patients is associated with congenital cardiovascular abnormalities. Some patients with UAPAs do not have associated cardiovascular abnormalities, called isolated UAPA. Patients with isolated UAPA generally have a mild clinical course and may not be diagnosed until adulthood, but repeated complications such as infections may make surgery difficult.
View Article and Find Full Text PDFPLoS One
October 2024
Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.
Positive end-expiratory pressure results in a sustained positive intrathoracic pressure, which exerts pressure on intrathoracic vessels, resulting in cardiopulmonary interactions. This sustained positive intrathoracic pressure is known to decrease cardiac preload, and thus, decrease venous return, ultimately reducing both the stroke volume and stressed blood volume of the cardiovascular system. Currently, cardiovascular and pulmonary care are provided independently of one another.
View Article and Find Full Text PDFActa Chir Belg
February 2025
Department of Pediatric Surgery, Saffier Network-ZNA Queen Paola Children's Hospital, Antwerp, Belgium.
Background: Congenital diaphragmatic hernia (CDH) is a rare developmental defect in the diaphragm, occurring in 2 in 10,000 births. Herniation of intraperitoneal organs through the diaphragmatic opening is always present, however few cases mention the herniation of retroperitoneal organs, such as a kidney. Due to the rarity of this condition, the optimal treatment strategy remains unclear.
View Article and Find Full Text PDFGenes Chromosomes Cancer
October 2024
Division of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan.
Purpose: Pleuropulmonary blastoma (PPB) is an infrequently encountered childhood malignant intrathoracic neoplasm associated with unfavorable clinical behavior. Since a well-characterized preclinical model is essential for developing competent agents for PPB, we aim to establish and characterize the world's first cell line of PPB, and attempt to perform the cytotoxicity assay on the PPB cell line.
Experimental Design: The index case is a 2-year-old female who developed a right thoracic tumor that was surgically removed and treated with multi-agent chemotherapy.
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