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Clinical and hematological profile of patients with pancytopenia at a tertiary medical center in Ethiopia.
Lab Med
September 2024
School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.
Background: Pancytopenia is an important hematological problem encountered in routine clinical practice associated with a multitude of disease states. The possible causes of pancytopenia can be influenced by geography, socioeconomic conditions, and endemic illnesses. Information regarding the underlying clinical conditions and morphologic features of blood cells of pancytopenia is limited and varied across different regions.
View Article and Find Full Text PDFHyperimmune malarial splenomegaly in a malaria-endemic area of southwest Burkina Faso: case of Bobo-Dioulasso.
BMC Infect Dis
August 2024
Souro Sanou University Hospital, Bobo Dioulasso, Higher Institute of Health Sciences, Nazi BONI University, Bobo Dioulasso, Burkina Faso, 01 BP 1091 Bobo-Dioulasso 01, Bobo-Dioulasso, Burkina Faso.
Introduction: Hyperreactive malarial splenomegaly (HMS) is one of the main causes of massive splenomegaly in malaria-endemic zones. Diagnosis is often challenging in Bobo-Dioulasso. This study aimed to describe the clinical and socio-demographic profile, and the reasons for delay in the diagnosis of HMS cases recorded in the Medicine and Medical Specialties wards of Souro Sanou Teaching hospital.
View Article and Find Full Text PDFType 1 Gaucher's Disease. A Rare Genetic Lipid Metabolic Disorder Whose Diagnosis Was Concealed by Recurrent Malaria Infections in a 12-Year-Old Girl.
J Blood Med
January 2024
Department of Pediatrics, Kabale University, Kabale, Uganda.
Introduction: Gaucher disease is a rare autosomal recessive lysosomal storage disease with unknown prevalence in Africa and no record of the disease exists in Uganda.
Case Presentation: We report a case of a 12-year-old female, the last born of 6 from a family with no known familial disease who presented with non-neuronopathic Gaucher disease and superimposed malaria. The disease was initially misdiagnosed as hyperreactive malarial splenomegaly but was subsequently confirmed by examination of the bone marrow smear and core.
Retention of uninfected red blood cells causing congestive splenomegaly is the major mechanism of anemia in malaria.
Am J Hematol
February 2024
UMR_S1134, BIGR, Inserm, Université de Paris, Paris, France.
Article Synopsis
- Splenomegaly, or spleen enlargement, is commonly found in patients with malarial anemia caused by Plasmodium falciparum or P. vivax, but the reasons for this connection are not fully understood.
- A study in Papua, Indonesia measured red blood cell (RBC) concentrations in the spleens of 37 patients, discovering that spleen size correlated positively with the amount of red-pulp and negatively with white-pulp, indicating a relationship between spleen composition and size.
- The research revealed that retained RBCs, primarily uninfected, accounted for significant blood loss in P. falciparum infections, and this retention correlated negatively with hemoglobin levels and circulating RBC counts, highlighting the impact
Tropical splenomegaly in a migrant-in-transit crossing the Darien gap, Panamá: A probable case of hyper-reactive malarial splenomegaly.
IDCases
September 2023
Instituto Conmemorativo de los Estudios de la Salud Panamá, Panama.
Hyper-reactive malarial splenomegaly (HMS), or tropical splenomegaly syndrome, is a severe complication of chronic and recurrent infections caused by . This condition typically results in splenomegaly greater than or equal to 10 cm and a constellation of laboratory findings, including the absence of identifiable parasites in peripheral blood smears. However, patients with HMS demonstrate serological or molecular evidence of infection.
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