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ESAT-6 protein suppresses allograft rejection by inducing CD4Foxp3 regulatory T cells through IκBα/cRel pathway.
Front Immunol
January 2025
Section of Immunology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Background: Maintenance immunosuppression is required for suppression of alloimmunity or allograft rejection. However, continuous use of immunosuppressants may lead to various side effects, necessitating the use of alternative immunosuppressive drugs. The early secreted antigenic target of 6 kDa (ESAT-6) is a virulence factor and immunoregulatory protein of mycobacterium tuberculosis (Mtb), which alters host immunity through dually regulating development or activation of various immune cells.
View Article and Find Full Text PDFEffects of CO and liquid digestate concentrations on the growth performance and biomass composition of and microalgal strains.
Front Bioeng Biotechnol
January 2025
APESA Pôle valorisation, Montardon, France.
This study evaluated the growth performance of and microalgae cultivated in diluted liquid digestate supplemented with CO, comparing their efficiency to that of a conventional synthetic media. The presence of an initial concentration of ammonium of 125 mg N-NH .L combined with the continuous injection of 1% v/v CO enhanced the optimal growth responses and bioremediation potential for both strains in 200-mL cultures.
View Article and Find Full Text PDFNurses' viewpoint of sustaining work despite musculoskeletal pain: A qualitative study.
J Educ Health Promot
December 2024
Health in Disasters and Emergencies Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Background: The nursing profession consistently has the highest rates of musculoskeletal disorders (MSDs) among occupations due to physical and psychological pressures, leading to an increased number of sickness absences, early retirement, staff shortage, poor health conditions, and need for medical care. Absence among healthcare workers puts the quality of patient care at risk, and increase colleagues' workload and employer staffing expenses. This study aimed to investigate the viewpoints of Iranian nurses about sustaining work despite musculoskeletal pain.
View Article and Find Full Text PDFCdkn1c orchestrates a molecular network that regulates the euploidy of the male mouse germline stem cells.
Development
January 2025
Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Karyotype instability in the germline leads to infertility. Unlike the female germline, the male germline continuously produces fertile sperm throughout life. Here we present a molecular network responsible for maintaining karyotype stability in the male mouse germline.
View Article and Find Full Text PDFA User-Centered Design Approach for a Screening App for People With Cognitive Impairment (digiDEM-SCREEN): Development and Usability Study.
JMIR Hum Factors
January 2025
Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Background: Dementia is a widespread syndrome that currently affects more than 55 million people worldwide. Digital screening instruments are one way to increase diagnosis rates. Developing an app for older adults presents several challenges, both technical and social.
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