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Olanzapine enhances early brain maturation through activation of the NODAL/FOXH1 axis.
iScience
October 2024
Department of Psychiatry, National Clinical Research Center for Mental Disorders, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
The portrayed effects of olanzapine on brain development and neuronal response remain unclear under the genetic background of . Here, we constructed therapeutic-dosage olanzapine-treated cerebral organoid (CO) models using induced pluripotent stem cells from human samples. We found that the activation of NODAL/FOXH1 axis mediated the early response to olanzapine up to day 15, which subsequently caused thicker cortical-like structures, cell identity maturation, higher stemness of neural progenitor cells (NPCs), and mature neuronal firing of early neurons in day 24.
View Article and Find Full Text PDFPsychotic Arousal and the Psychopathology of Acute Schizophrenia: An Exploratory Study of the Experiential Emotional State in Acute Psychosis.
J Clin Med
September 2024
University Mental Health Research Institute, 11527 Athens, Greece.
: Increasing research data suggest that the dysfunction of emotional brain systems may be an important contributor to the pathophysiology of schizophrenia. However, contemporary psychopathology consistently underestimates the role of emotions in the phenomenology of the disease. Psychotic arousal (PA) is a conceptually defined psychopathological construct aiming to portray the experiential emotional state of acute psychosis.
View Article and Find Full Text PDFIn silico analysis predicts mutational consequences of CITED2, NUDT4, and Ar18B in patients with bipolar disorder.
Behav Brain Res
January 2025
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, 226028, India. Electronic address:
Bipolar disorder is a mood-related disorder, which can be portrayed as extreme shifts in energy, mood, and activity levels which can also be characterized by manic highs and depressive lows that can be often misdiagnosed as unipolar disorder due to primitive diagnostics techniques based on clinical assessments as well as diagnostic complexities arising due to its heterogeneous nature and overlapping symptoms with conditions like schizophrenia. leading to delays in treatment Strong evidence in support of genetic and epigenetic aspects of bipolar disorder, including mechanisms such as compromised hypothalamic-pituitary-adrenal axis, immune-inflammatory imbalances, oxidative stress, and mitochondrial dysfunction are found. Moreover, some previous research has already stated the role of genes like CITED2, NUDT4, and Arl8B in these processes.
View Article and Find Full Text PDFSimulation with a standardised patient to reduce stigma towards people with schizophrenia spectrum disorder among nursing students: A quasi-experimental study.
Arch Psychiatr Nurs
October 2024
Fundación Jiménez Díaz School of Nursing - Universidad Autónoma de Madrid, Health Research Institute-Fundación Jiménez Díaz University Hospital - UAM (IIS-FJD, UAM), Avda. de los Reyes Católicos, 2, 28040 Madrid, Spain. Electronic address:
Objectives: This study examined the effectiveness of simulation with a standardised patient on the perception of stigma associated with schizophrenia among undergraduate nursing students. It also assessed the reliability of the AQ-27 questionnaire in this context.
Method: A quasi-experimental study without a control group was conducted on a non-probabilistic sample.
Analysis of Spanish-Language News Reports on Schizophrenia and Psychosis.
Psychiatr Serv
December 2024
George Warren Brown School of Social Work (all authors) and Center for Mental Health Services Research (Pérez-Flores, Cabassa), Washington University in St. Louis, St. Louis.
Objective: Stigma toward individuals with schizophrenia and psychosis has been widely studied in the general population, but research on Spanish-language news media coverage of these mental disorders in the Latinx population is limited. The authors aimed to examine how schizophrenia and psychosis are commonly presented in U.S.
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