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Transgenerational Reproductive and Developmental Toxicity Induced by N-Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster.
J Appl Toxicol
January 2025
Laboratorio de Genética y Toxicología Ambiental-Banco de Moscas, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico.
N-Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as a potent hepatotoxin, promutagen, and probable human carcinogen; this is because of the metabolites associated with its biotransformation. The metabolism of NDMA produces formaldehyde, another alkylating agent and DBP. Both compounds are generated from natural and anthropogenic sources, but the safety restrictions applied to NDMA do not extend to the uses of formaldehyde.
View Article and Find Full Text PDFGenotoxic effects of NDMA-contaminated ranitidine on Allium cepa cells and unveiling carcinogenic mechanisms via DFT and molecular dynamics simulation study.
Sci Rep
December 2024
Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205, Bangladesh.
This study investigated the potential genotoxic and carcinogenic effects of N-nitrosodimethylamine (NDMA), a hazardous compound found in ranitidine formulations that are used to treat excessive stomach acid. The study first examined the effects of NDMA-contaminated ranitidine formulation on Allium cepa root growth and mitotic activity. The results demonstrated dose-dependent decreases in both root growth and mitotic index indicating genotoxicity and cell division disruption.
View Article and Find Full Text PDFPhotocatalytic degradation of tetracycline antibiotics and elimination of N-nitrosodimethylamine formation potential by BiOCl/ZnInS heterostructure under visible-light irradiation.
J Environ Manage
January 2025
State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, PR China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, PR China.
Photocatalysis is an effective method for removing tetracycline antibiotics, which are important precursors to the potential carcinogen N-nitrosodimethylamine (NDMA). Herein, a BiOCl/ZnInS heterojunction was successfully synthesized using a simple hydrothermal method. This heterojunction was applied for the first time to degrade various tetracycline antibiotics and reduce NDMA formation potential (NDMA-FP) under visible-light irradiation.
View Article and Find Full Text PDFNitrite leads to the formation of N-nitrosodimethylamine during sulfate radical oxidation of dimethylamine compounds.
Water Res
March 2025
Department of Environmental Science and Engineering, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:
Sulfate radical (SO) advanced oxidation processes (SR-AOPs) are efficient for degrading a broad spectrum of contaminants. This study demonstrates that the existence of environmentally relevant concentrations of nitrite (NO) can lead to the formation of N-nitrosodimethylamine (NDMA), a probable human carcinogen, when heat activated peroxydisulfate (heat/PDS) is applied to address contaminants with dimethylamine moieties, such as tetracyclines. NO effectively competes with tetracyclines for SO at a high second-order reaction rate constant of 8.
View Article and Find Full Text PDFNDMA enhances claudin-1 and -6 expression viaCYP2E1/ROS in AGS cells.
Toxicol In Vitro
January 2025
Laboratorio de Inmunobiología, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM, Mexico. Electronic address:
Carcinogenic N-nitroso compounds, especially N-nitroso dimethylamine, increase the risk of gastric cancer development. Cytochrome P450-2E1 metabolizes this compound, thus generating an oxidant microenvironment. We aimed to evaluate in gastric adenocarcinoma cells if its effect on CYP2E1 and ROS affects signaling pathways associated with gastric cancer oncogenesis.
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