[Analysis of Myc gene family in laryngeal cancer].

Zhonghua Er Bi Yan Hou Ke Za Zhi

Department of Otolaryngology Head and Neck Surgery, First Teaching Hospital, Norman Bethune University of Medical Sciences, Changchun 130021.

Published: October 1998

Objective: To study the abnormal amplification and role of Myc gene family in the development of laryngeal cancer.

Method: A PCR-PAGE-Laser scanning technique was applied.

Results: There was no Myc gene amplification in the normal laryngeal tissues. The abnormal L-myc and C-myc gene were positive in 47% (15/32) of laryngeal cancers and 41% (13/32) of the cancers shown the N-myc gene amplification. Myc gene amplification was not related to age, sex and differentiation (P > 0.05), but the N-myc amplification was higher in patients with lymph node metastasis (P < 0.05).

Conclusion: The N-myc amplification may play a role of positive regulation in the lymph metastasis of laryngeal cancer. The abnormal amplification of Myc gene family is one of the causes in development of laryngeal cancer.

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