Deracemization of racemic 4-pyridyl-1-ethanol by Catharanthus roseus cell cultures.

Phytochemistry

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, 422-8526, Shizuoka, Japan

Published: November 1998

Immobilized cells of Catharanthus roseus synthesized (R)-4-pyridyl-1-ethanol from the corresponding racemate in 100% yield by stereoinversion of the (S)-alcohol in the racemate to the (R)-alcohol. Furthermore, in the reduction of 4-acetylpyridine, we could synthesize both (R) and (S)-4-pyridyl-1-ethanol during a short or a long incubation.

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http://dx.doi.org/10.1016/s0031-9422(98)00241-6DOI Listing

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