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Syk inhibitors reduce tau protein phosphorylation and oligomerization.
Neurobiol Dis
October 2024
Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Spleen tyrosine kinase (Syk), a non-receptor-type tyrosine kinase, has a wide range of physiological functions. A possible role of Syk in Alzheimer's disease (AD) has been proposed. We evaluated the localization of Syk in the brains of patients with AD and control participants.
View Article and Find Full Text PDFA case report of bullous pemphigoid following secukinumab therapy for a patient with psoriasis.
J Dermatolog Treat
December 2024
Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Bullous pemphigoid induced by secukinumab in treatment of psoriasis is rare. We report a 49-year-old man with psoriasis who developed bullous pemphigoid during treatment with secukinumab. Scattered tense vesicles with itching appeared all over the body after the fourth treatment.
View Article and Find Full Text PDFGranular C3 dermatosis-A report of two cases and a mini-review of literature.
J Dermatol
December 2024
Department of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Article Synopsis
- - Granular C3 dermatosis (GCD) presents with skin lesions similar to dermatitis herpetiformis and is characterized by the deposition of complement C3 and C5b-9 at the epidermal basement membrane zone, as seen in direct immunofluorescence tests.
- - Two cases of GCD highlighted different symptoms: a 49-year-old man with itchy blisters and a 53-year-old woman with widespread pruritic papules and blisters, both showing eosinophilia and specific histopathological features.
- - Treatment for GCD included topical steroids and oral medications for the first patient with success, while the second patient improved with oral steroids but had some lingering symptoms; overall awareness and
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation.
Dermatol Online J
October 2023
Division of Dermatology, Tokushima Red Cross Hospital, Komatsushima, Tokushima, Japan.
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs.
View Article and Find Full Text PDFInterventions for bullous pemphigoid.
Cochrane Database Syst Rev
August 2023
Department of Dermatology, St George Hospital & University of New South Wales, Sydney, Australia.
Background: Bullous pemphigoid (BP) is the most common autoimmune blistering disease. Oral steroids are the standard treatment. We have updated this review, which was first published in 2002, because several new treatments have since been tried.
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