The onset and distribution of calbindin (CB) and parvalbumin (PV) immunoreactivity were investigated in the lateral geniculate nuclear complex and the olivary pretectal nucleus (OPT) in developing rats. CB expression occurred early (before eye-opening) in the relay neurons of the intergeniculate leaflet, parvocellular portion of the ventral lateral geniculate nucleus and OPT relating to ambient vision mediated by W-like retinal ganglion cells. On the contrary, PV expression occurred late (after eye-opening) in the relay neurons of the magnocellular portion of the ventral lateral geniculate nucleus (VLGMC) and OPT relating to focal vision mediated by Y-like retinal ganglion cells. A unilateral eye enucleating experiment indicated that the VLGMC and OPT received dense input from PV-positive Y-like retinal ganglion cells. The results show the different onsets of CB and PV expressions in the retino-recipient thalamic and pretectal nuclei receiving inputs from different kinds of retinal ganglion cells.
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