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Locoregional anesthesia in patients with Brugada syndrome. A retrospective database analysis.
Acta Anaesthesiol Scand
February 2025
Department of Anesthesiology and perioperative medicine, University Hospital of Brussels, Free University of Brussels, Brussels, Belgium.
Background: The use of local anesthetics (LA) in individuals with Brugada syndrome (BrS) remains a subject of debate due to the lack of large-scale studies confirming their potential risks. This study primarily aimed to evaluate the incidence of new malignant arrhythmias or defibrillation events in patients diagnosed with BrS during the perioperative period, following the administration of local anesthetics, and within 30 days postoperatively. The secondary objective was to analyze the occurrence of adverse effects during hospitalization, as well as 30-day readmission and mortality rates.
View Article and Find Full Text PDFNovel real-time automation of combined frequency and low voltage substrate mapping to guide ablation for Brugada syndrome: a case report.
Eur Heart J Case Rep
November 2024
Heart Rhythm Research Group, Division of Biomedical Sciences, Warwick Medical School, Clinical Sciences Research Laboratory, Clifford Bridge Road, Coventry CV2 2DX, UK.
Article Synopsis
- Brugada syndrome (BrS) is a hereditary heart condition that raises the risk of sudden cardiac death due to dangerous heart rhythms, and catheter ablation can help reduce these risks by targeting specific areas in the heart.
- A 66-year-old male with BrS underwent a unique catheter ablation procedure using automated frequency mapping to locate and treat problematic heart regions, showing a significant reduction in dangerous heart abnormalities.
- Follow-up results indicated successful outcomes with normalized ECG and no further occurrences of ventricular arrhythmias, highlighting the effectiveness of this automated mapping and ablation strategy.
The synthetic chemistry of sarpagine-ajmaline-type alkaloids.
Alkaloids Chem Biol
October 2024
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, Yunnan, P. R. China. Electronic address:
The sarpagine-ajmaline type monoterpenoid indole alkaloids are among the most important groups of natural alkaloids, and the complex polycyclic and cage-like architectures present significant synthetic challenges. Because of their characteristic indole-fused azabicyclo[3.3.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the diagnostic process of Brugada syndrome (BrS) using ajmaline to expose the Type 1 Brugada pattern in patients, highlighting limited data on different populations.
- It analyzed 260 patients (average age 43.4, mostly males) who underwent ajmaline tests, revealing a significant number with syncope history and family backgrounds of BrS or sudden cardiac death.
- Results showed that less than half of the subjects met the current diagnostic criteria for BrS, but the overall rate of serious arrhythmia events was low over a median follow-up period of three years.
Type 1 Brugada Pattern May Be Provoked by Ajmaline in Some Healthy Subjects: Results From a Clinical Trial.
Circulation
May 2024
Cardiology Section and Cardiovascular Clinical Academic Group, St. George's University Hospitals NHS Foundation Trust, and Institute of Molecular and Clinical Sciences, St. George's University of London, UK (B.E., C.S., D.J., Y.D.W., R.B., B.G., C.M., Y.B.-H., S.P., S.S., M.P., E.R.B.).
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