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Biomechanical modeling combined with pressure-volume loop analysis to aid surgical planning in patients with complex congenital heart disease.
Med Image Anal
December 2024
Division of Pediatric Cardiology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address:
Patients with congenitally corrected transposition of the great arteries (ccTGA) can be treated with a double switch operation (DSO) to restore the normal anatomical connection of the left ventricle (LV) to the systemic circulation and the right ventricle (RV) to the pulmonary circulation. The subpulmonary LV progressively deconditions over time due to its connection to the low pressure pulmonary circulation and needs to be retrained using a surgical pulmonary artery band (PAB) for 6-12 months prior to the DSO. The subsequent clinical follow-up, consisting of invasive cardiac pressure and non-invasive imaging data, evaluates LV preparedness for the DSO.
View Article and Find Full Text PDFThe implementation of speckle tracking echocardiography for cardiac resynchronization therapy optimisation. A rotational myocardial mechanics interpretation.
Echo Res Pract
December 2024
1st Cardiology Department, General Hospital of Nikea, Agios Panteleimon, 3 D. Mantouvalou str., 18454, Athens, Greece.
Article Synopsis
- Cardiac resynchronization therapy (CRT) enhances left ventricular function in heart failure patients, but its mechanisms remain partly unclear; this study aimed to investigate these mechanisms using 2D speckle tracking echocardiography (2D-STE).
- The study involved 46 patients who underwent CRT and evaluated their cardiac performance at baseline and post-CRT implementation through 2D-STE and a 6-minute walk test, observing a 48% response rate at 6 months, particularly in those with dilated cardiomyopathy.
- Optimizing CRT by adjusting the activation timing of the ventricular electrodes was found to significantly improve left ventricular function, with improvements in effective stroke volume and rotational mechanics serving as key indicators of successful therapy
Hemodynamic Effects and Clinical Outcomes of Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO) in Cardiogenic Shock.
Am J Cardiol
February 2025
Structural Heart Disease, Heart and Vascular Services, Henry Ford Hospital, Detroit, Michigan.
Left atrial veno-arterial extracorporeal membrane oxygenation (LAVA-ECMO) in cardiogenic shock (CS) is a novel mechanical cardiocirculatory support strategy that provides robust cardiocirculatory support and simultaneous left and right atrial venting by way of a multifenestrated transeptal catheter. We performed a single-center retrospective analysis of all patients aged ≥18 years with CS who underwent LAVA-ECMO at a quaternary care institution from 2018 to 2023. Clinical outcomes and prehemodynamics and posthemodynamics were evaluated.
View Article and Find Full Text PDFDreaming of electrical waves: Generative modeling of cardiac excitation waves using diffusion models.
APL Mach Learn
September 2024
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA.
Electrical waves in the heart form rotating spiral or scroll waves during life-threatening arrhythmias, such as atrial or ventricular fibrillation. The wave dynamics are typically modeled using coupled partial differential equations, which describe reaction-diffusion dynamics in excitable media. More recently, data-driven generative modeling has emerged as an alternative to generate spatio-temporal patterns in physical and biological systems.
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