A patient with long-standing nodular mastocytosis developed a slate-blue lesion on the scalp which produced symptoms of histamine release on mechanical and thermal stimulation. Light and electron microscopic examination of the lesion showed zones of mast cells and zones of melanized cells. A transition zone showing cells with dual (melanosomal and mast) granulation, as well as granules representing intergrades between classical mast granules and melanosomes, was present. Features of this lesion add to the accumulated evidence that there is a histogenetic relationship between mast cells and melanocytes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0190-9622(79)70027-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Histological characterization of liver involvement in systemic mastocytosis.
Liver Int
July 2024
CEREMAST, Hematology Institute, Normandy University School of Medicine, Caen, France.
Background And Aims: Systemic mastocytosis (SM) is characterized by the accumulation of atypical mast cells (MCs) in organs. Liver histology of SM has been marginally described and accurate histological classification is critical, given the consequences of aggressive SM diagnosis. We aimed to describe the histological features associated with liver SM using updated tools.
View Article and Find Full Text PDFChallenges in the Diagnosis of Cutaneous Mastocytosis.
Diagnostics (Basel)
January 2024
St John's Institute of Dermatology, Guy's Hospital, London SE1 9RT, UK.
Background: Mastocytosis is characterized by an accumulation of clonal mast cells (MCs) in tissues such as the skin. Skin lesions in mastocytosis may be clinically subtle or heterogeneous, and giving the correct diagnosis can be difficult.
Methods: This study compiles personal experiences together with relevant literature, discussing possible obstacles encountered in diagnosing skin involvement in mastocytosis and cutaneous mastocytosis (CM).
Current Challenges in the Diagnosis of Pediatric Cutaneous Mastocytosis.
Diagnostics (Basel)
December 2023
Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.
Article Synopsis
- - Pediatric mastocytosis is mainly a skin disease known as cutaneous mastocytosis (CM), characterized by the buildup of mast cells in the skin without affecting other areas of the body.
- - CM can be categorized into three forms: maculopapular CM (most common), diffuse CM (rare and severe), and mastocytoma (involves solitary or small nodular lesions).
- - While childhood MPCM and mastocytoma are often benign and may resolve on their own, diffuse CM can lead to severe symptoms and a higher risk of anaphylaxis, and systemic mastocytosis is rare in children.
Aggressive systemic mastocytosis of colon and lymph node: A case report.
Medicine (Baltimore)
May 2023
Vascular Surgery, Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China.
Rationale: Mastocytosis is a group of rare neoplastic diseases characterized by monoclonal proliferation of mast cells in the skin or other tissues and organs, including cutaneous mastocytosis and systemic mastocytosis (SM). Mastocytosis can also occur in the gastrointestinal tract, mostly manifested as increased mast cells dispersed in various layers of the intestinal wall; a few may present as polypoid nodules, but rarely as soft tissue mass formation. Pulmonary fungal infections mostly occur in patients with low immune function and have not been reported in the literature as the initial manifestation in patients with mastocytosis.
View Article and Find Full Text PDFA Case of Systemic Mastocytosis Diagnosed Endoscopically.
Cureus
December 2022
Gastroenterology, St. Joseph's Regional Medical Center, Paterson, USA.
Mastocytosis, or mast cell proliferation, is very rare. Overall, 60% of patients with systemic mastocytosis (SM) have gastrointestinal involvement, with the colon being the most prevalent affected site. Most patients are diagnosed by bone marrow biopsy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!