[Cytogenetic defects in lymphocytes of patients with chronic opisthorchiasis concurrent with Epstein-Barr virus persistence].

Sixty three patients with chronic opisthorchiasis were cytogenetically, serologically, and biochemically studied. Most patients with opisthorchiasis were found to have higher or high titers of antibodies to Epstein-Barr viral antigens. There was a direct correlation between the titers of antibodies to Epstein-Barr virus capsid antigen and the count of cytogenetically damaged cells. The majority of opisthorchiasis patients with superinvasion, hepatic, pancreatic, and oropharyngeal diseases showed a great increase in the titers of antibodies to Epstein-Barr virus antigens and a high persistence and in the cytogenetically damaged lymphocytes. Opisthorchiasis patients with high antibody titers to Epstein-Barr virus capsid antigens showed a considerable decrease in the parameters of the peripheral antioxidative system.