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Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
Int J Mol Sci
May 2023
Department of Medical Oncology, Amsterdam University Medical Centers, Location VUmc, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands.
Malignant Pleural Mesothelioma (MPM) is a rare neoplasm that is typically diagnosed in a locally advanced stage, making it not eligible for radical surgery and requiring systemic treatment. Chemotherapy with platinum compounds and pemetrexed has been the only approved standard of care for approximately 20 years, without any relevant therapeutic advance until the introduction of immune checkpoint inhibitors. Nevertheless, the prognosis remains poor, with an average survival of only 18 months.
View Article and Find Full Text PDFA Wearable Electrochemical Gas Sensor for Ammonia Detection.
Sensors (Basel)
November 2021
Dipartimento di Chimica Industriale "Toso Montanari", Università di Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy.
The next future strategies for improved occupational safety and health management could largely benefit from wearable and Internet of Things technologies, enabling the real-time monitoring of health-related and environmental information to the wearer, to emergency responders, and to inspectors. The aim of this study is the development of a wearable gas sensor for the detection of NH at room temperature based on the organic semiconductor poly(3,4-ethylenedioxythiophene) (PEDOT), electrochemically deposited iridium oxide particles, and a hydrogel film. The hydrogel composition was finely optimised to obtain self-healing properties, as well as the desired porosity, adhesion to the substrate, and stability in humidity variations.
View Article and Find Full Text PDFThis last part of the oxygen story seems to stray from the line followed till now, and contradict itself, by electing ATP instead of oxygen as its protagonist. Yet, of course, this deviation is only apparent: in reality the hypoxanthine, which is at the basis of the production of superoxide, during the post-ischemic perfusion, is just a catabolic product of the intercellular reserves of ATP, pillaged by the ischemia itself. The attempts to resolve the ischemia and cellular anoxia through the supply, added to the volemic and respiratory reintegration, of performed packets of energy, such as ATP with MgCl2, FDP, etc.
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