Objective: The causes of hypopituitarism in adult life are most frequently cerebral tumors, pituitary infarction, head trauma, pituitary surgery, or irradiation. We report a case of hypopituitarism after surgical clipping of a ruptured cerebral aneurysm. Two previous cases after the rupture of a cerebral aneurysm have been reported.
Design: Case report.
Patients: One 42-yr-old man.
Measurements And Main Results: A 42-yr-old man was admitted as an emergency for unconsciousness. The computed tomography showed a massive subarachnoid hemorrhage, and specific angiography showed an aneurysm in the internal carotid. The aneurysm was successfully clipped through craniotomy. The patient's hospital course was marked by a few episodes of pulmonary infection, and a tracheotomy was performed. The patient was transferred to the rehabilitation unit; he received a rating of 9 on the Glasgow Coma Scale. Seven months after rupture of the aneurysm, the patient was readmitted to the intensive care unit for septic shock, with pulmonary infection associated with vomiting and diarrhea. Despite standard therapy and inotropic support, there was no improvement of his clinical condition. Adrenal failure was then suspected. Treatment was started immediately with hydrocortisone (50 mg) four times a day. Within hours, his clinical condition improved. The following month, the patient was weaned off his tracheotomy and had nearly recovered. Endocrine tests confirmed the cortisol insufficiency but also hypothyroidism and hypogonadotropic hypogonadism secondary to hypopituitarism.
Conclusion: Our case is the first one reported of hypopituitarism after surgical clipping of a ruptured cerebral aneurysm.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00003246-200111000-00028 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis.
Neurol Res
March 2025
Neurovascular Center, Naval Medical University Changhai hospital, Shanghai, China.
Background: While existing research has established a link between dietary habits and the incidence of intracranial aneurysms, the application of Mendelian randomization to explore this association remains largely uncharted.
Methods: In our study, we analyzed a wide array of dietary factors using data from the IEU Open GWAS project, which included meat varieties, vegetarian foods, cereal and the frequency of alcohol intake. We included pooled intracranial aneurysm GWAS data from a comprehensive dataset of 7,495 cases.
Development and Validation of Machine Learning Models for Outcome Prediction in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage Following Endovascular Treatment.
Ther Clin Risk Manag
March 2025
Department of Neurosurgery, The second Affiliated Hospital, Jiangxi Medical College of Nanchang University, Nanchang, 330006, People's Republic of China.
Background: Endovascular treatment (EVT) has been recommended as a superior modality for the treatment of intracranial aneurysm. However, there still exists a worse percentage of poor functional outcome in patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) undergoing EVT. Therefore, it is urgently needed to investigate the risk factors and develop a critical decision model in the subtype of such patients.
View Article and Find Full Text PDFEvaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model.
Front Bioeng Biotechnol
February 2025
Biomedical Engineering and Physiology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, United States.
Introduction: Flow diverters are specialized stents used to treat intracranial aneurysms. Bioresorbable flow diverters (BRFDs) have been proposed as the next-generation of flow diverter technology. BRFDs aim to occlude and heal the aneurysm before safely dissolving into the body, mitigating complications associated with the permanent presence of conventional flow diverters.
View Article and Find Full Text PDFEffects of the Japanese traditional medicine Goreisan on adverse events affecting mucosal edema in patients with subarachnoid hemorrhage treated with clazosentan.
Neurosurg Rev
March 2025
Department of Neurosurgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba-cho, Yahaba, Iwate, 028-3694, Japan.
Despite successful management of pulmonary complication with fluid restriction protocol in aneurysmal subarachnoid hemorrhage (aSAH) patients treated with clazosentan, management of symptoms related to mucosal edema, such as diarrhea, stuffy nose, and difficulty in breathing, remains challenging. Hence, we investigated the effect of Goreisan shown to be effective in the treatment of symptoms related with mucosal edema in aSAH patients treated with clazosentan. Patients with aSAH who received clazosentan for vasospasm after aneurysm obliteration were prospectively enrolled in the study.
View Article and Find Full Text PDFPlasma lipidome and intracranial aneurysms: A univariable and multivariable Mendelian randomization study.
Neuroscience
March 2025
Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: Recent studies suggest that plasma lipids, including lipoproteins and fatty acids, may contribute to the pathogenesis of intracranial aneurysms (IAs). However, the relationship between a broader range of plasma lipids and IA risk remains unclear. This study uses the Mendelian randomization (MR) approach to explore the causal relationships between 179 plasma lipids and the risk of IAs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!