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Brain Commun
February 2025
Centre for Medical Image Computing, Department of Computer Science, University College London, London WC1V 6LJ, UK.
Although the corticobasal syndrome was originally most closely linked with the pathology of corticobasal degeneration, the 2013 Armstrong clinical diagnostic criteria, without the addition of aetiology-specific biomarkers, have limited positive predictive value for identifying corticobasal degeneration pathology in life. Autopsy studies demonstrate considerable pathological heterogeneity in corticobasal syndrome, with corticobasal degeneration pathology accounting for only ∼50% of clinically diagnosed individuals. Individualized disease stage and progression modelling of brain changes in corticobasal syndrome may have utility in predicting this underlying pathological heterogeneity, and in turn improve the design of clinical trials for emerging disease-modifying therapies.
View Article and Find Full Text PDFAm J Forensic Med Pathol
March 2025
From the Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.
Calciphylaxis, or calcific uremic arteriolopathy, is a rare condition with a poorly understood pathophysiology. It is often associated with diseases that cause abnormalities in calcium metabolism, such as end-stage renal disease (ESRD) and hyperparathyroidism. While it most often affects the skin, involvement of extracutaneous organs, called systemic calciphylaxis, has been reported.
View Article and Find Full Text PDFBMC Cardiovasc Disord
March 2025
Faculty of Medicine, Department of Forensic Medicine, Pamukkale University, Kınıklı Kampüsü, 20200, Denizli, Türkiye.
Background: Atherosclerosis is the most common cause of cardiovascular-cerebrovascular diseases. Obesity and atherosclerosis are related, and obesity can lead to systemic diseases and an increase in organ weight. Anthropometric measurements such as body mass index, waist circumference and hip circumference are used to determine the risk of obesity.
View Article and Find Full Text PDFPathologie (Heidelb)
March 2025
Institut für Pathologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Deutschland.
The teaching of pathology at the 36 university departments of pathology is influenced by different curriculum structures. Teaching formats and the number of course hours vary considerably in some cases, partly due to structural circumstances at different locations. The teaching content appears to be largely congruent.
View Article and Find Full Text PDFVirchows Arch
March 2025
Department of Pathology, Kantonsspital Winterthur, Brauerstrasse 15, 8401, Winterthur, Switzerland.
Historically, autopsy has served as a procedure to determine the cause of death. With the surge in diagnostic techniques and a change in mindset, autopsy rates have decreased globally to less than 10%. Besides providing the cause of death and insights into disease mechanism, autopsy may assess clinical performance via discrepancy analysis.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
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