The trial of ketanov, nonnarcotic nonsteroidal antiinflammatory drug with potent analgetic effect, allows to recommend its wider use in dentistry.
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Comparison of Intravenous Ibuprofen Versus Intravenous Ketorolac in Acute Postoperative Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Cureus
November 2024
Anesthesiology, Dr. L. H. Hiranandani Hospital, Mumbai, IND.
Non-steroidal anti-inflammatory drugs (NSAIDs) are popularly used in the management of acute postoperative pain. Intravenous (IV) ketorolac has been used for several years for this purpose. Recently, IV ibuprofen has been introduced for the management of postoperative pain.
View Article and Find Full Text PDFComparing the Postoperative Analgesic Efficacy of Ketorolac and Tramadol After Open Inguinal Hernia Mesh Repair: A Randomized Controlled Trial.
Cureus
October 2024
General Surgery, Pakistan Air Force Hospital, Islamabad, PAK.
Background Opioids are the mainstay for postoperative pain control. However, due to the increasing dependence on opioids and their side effects, multiple adjuncts are used to reduce opioid consumption, including non-steroidal anti-inflammatory drugs (NSAIDs). Inguinal hernia repair is one of the most common procedures performed by general surgeons worldwide.
View Article and Find Full Text PDFDevelopment and in vitro-in vivo evaluation of ocular insert containing ketorolac tromethamine and moxifloxacin hydrochloride.
Ann Pharm Fr
January 2025
L.M. College of Pharmacy, Ahmedabad, India. Electronic address:
Purpose: Conjunctivitis is a common eye disorder that causes swelling and inflammation of the conjunctiva. Topical dosage form containing antibiotics and non-steroidal anti-inflammatory drugs are prescribed for the treatment and in order to overcome problems of conventional dosage forms the present study aims to develop an ocular insert containing moxifloxacin HCl and ketorolac tromethamine.
Methods: Insert was prepared by a solvent casting method by taking different polymers PVA, PVP K-30, and a combination of both as film-forming polymer, and glycerol as a plasticizer and characterized by various parameters like thickness, folding endurance, pH, swelling index, drug content, mechanical properties, in vitro and in vivo release study.
Efficacy of Ketorolac Tromethamine Diluted Saline Irrigant on Postoperative Sequelae in Patients Undergoing Lower Third Molar Impaction Surgery: A Prospective Clinical Study.
Cureus
August 2024
Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Background Lower third molar surgery is very commonly performed for minor oral surgery by an oral and maxillofacial surgeon. One of the main chief complaints that patients report back to the clinic after getting their lower third molar impaction surgery is immediate postoperative pain. In our study, we have compared the efficacy of ketorolac tromethamine diluted saline solution over plain saline solution used as an irrigant in reducing postoperative swelling and pain.
View Article and Find Full Text PDFA Novel Formulation of Ketorolac Tromethamine (NTM-001) in Continuous Infusion in Adults with and without Renal Impairment: A Randomized Controlled Pharmacologic Study.
Adv Ther
September 2024
NorthStar Consulting, LLC, Davis, CA, USA.
Introduction: There is a medical need for a safe, effective nonopioid postoperative analgesic for older subjects, including those with mild to moderate renal impairment.
Methods: Participants (≥ 65 years) were stratified by no, mild, or moderate renal impairment defined as creatinine clearance 60-89 mL/min for mild and 30-59 mL/min for moderate. Subjects were randomized to receive a loading dose of 6.
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