Changes were studied in processes of peroxide oxidation of lipid (LPO), such as neutral lipids and phospholipids, as related to the levels of hemoglobin (Hb) and its derivatives, methemoglobin (Met-Hb) and carboxyhemoglobin (CO-Hb) in erythrocytes and blood plasma of 33 patients with iron-deficiency anemia (IDA). It has been found out that in IDA, decline in the concentration of Hb correlates with augmentation of the content of Met-Hb (r = -0.670, P = 0.038). Increase in the level of Met-Hb is accompanied by an accumulation in erythrocytes of Schiff bases as the final products of phospholipids peroxidation (r = 0.586, P = 0.004), CO-Hb-substrates of LPO (r = 0.425, P = 0.049), primary (r = 0.453, P = 0.04) and secondary (r = 0.438, P = 0.048) molecular products of peroxide oxidation of neutral lipids. A mechanism is discussed of the Hb derivatives Met-Hb and CO-Hb concurrence in the activation of LPO in IDA.
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