The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).
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Article Synopsis
- Pregnancy adds complexity to managing lipodystrophy disorders, which have been underreported in terms of related comorbidities and risks for women.
- A case study highlights a successful pregnancy in a 28-year-old woman with acquired partial lipodystrophy, showing improved glucose control but also leading to preterm delivery and maternal cardiac issues.
- Research indicates that while many women with various lipodystrophy phenotypes have successful pregnancies, they face high risks, necessitating intensive, multidisciplinary care and further investigation into leptin levels during pregnancy.
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