The effect of early surgical intervention (ESI) on immune homeostasis in children with burn was studied. The results of examination of 102 children aged from 1 to 5 years old with burn injury are given. In 62 children ESI with simultaneous autodermoplastics was performed; further 40 underwent standard treatment. Together with immune status improvement after ESI, the general condition of children improved, the clinical course of burn disease was abortive, which contributed to prevention of pyo-septical complications. Application of the conception of ESI permitted to decrease mortality in children with burns.

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