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The up-regulation of RIPK3 mediated by ac4C modification promotes oxidative stress-induced granulosa cell senescence by inhibiting the Nrf2/HO-1 pathway.
IUBMB Life
January 2025
Department of Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Abnormality of granulosa cells (GCs) is the critical cause of follicular atresia in premature ovarian failure (POF). RIPK3 is highly expressed in GCs derived from atretic follicles. We focus on uncovering how RIPK3 contributes to ovarian GC senescence.
View Article and Find Full Text PDFAnti-Müllerian hormone regulates ovarian granulosa cell growth in PCOS rats through SMAD4.
Int J Gynaecol Obstet
January 2025
Center for Reproductive Medicine, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Objective: Polycystic ovary syndrome (PCOS) is a diverse condition with an unknown cause. The precise mechanism underlying ovulatory abnormalities in PCOS remains unclear. It is widely believed that malfunction of granulosa cells is the primary factor contributing to aberrant follicular formation in PCOS.
View Article and Find Full Text PDFAssociation of pentachlorophenol in urine and follicular fluid with ovarian reserve and reproductive outcomes among women undergoing in vitro fertilization based on a prospective cohort study.
Environ Res
January 2025
Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, School of Public Health, Guilin Medical University, Guilin, 541199, PR China. Electronic address:
Pentachlorophenol (PCP), a persistent organic pollutant, has endocrine disrupting properties and there may be a link between its exposure and reproductive outcomes. In this study, we assessed the relationship of PCP exposure levels with ovarian reserve markers and reproductive health outcomes in women (N = 656) undergoing in vitro fertilization (IVF). PCP concentrations were determined in urine (n = 1,968; repeated measures) and follicular fluid samples (n = 603).
View Article and Find Full Text PDFReproductive outcomes in female mice offspring due to maternal metformin treatment.
Life Sci
January 2025
Studies of the Physiopathology of the ovary laboratory, Institute of Biology and Experimental Medicine (IBYME) - National Scientific and Technical Research Council (CONICET), Vuelta de Obligado 2490, C1428ADL Buenos Aires, Argentina. Electronic address:
Aims: Metformin has shown beneficial effects on reproduction in women. However, its use during pregnancy remains controversial, as metformin can cross the placenta. Most studies have focused on the metabolic impact on the offspring of treated mothers, with limited information regarding its reproductive effects.
View Article and Find Full Text PDFDeterminants of fertility in timed artificial insemination programs in beef cattle: predictive ability and risk factors from almost 2 million data points.
Animal
December 2024
Alta Genetics Brasil Ltda., Uberaba 38055-010, Brazil.
Timed artificial insemination (TAI) is a technology widely used in cattle production based on controlling ovarian follicular growth. This study analyzed a large database aiming to determine the influence of several intrinsic and extrinsic female factors, as well as their interactions to determine risk factors and produce prediction ability in beef cattle. A total of 1 832 999 TAIs conducted on 2 002 farms across South American countries were considered for the analysis, including 15 main fixed effects or interactions in the statistical model, in addition to five random effects.
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