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Differential Cytotoxicity and Inflammatory Responses to Particulate Matter Components in Airway Structural Cells.
Int J Mol Sci
January 2025
Lung Biology, Department of Experimental Medical Sciences, Lund University, 221 84 Lund, Sweden.
Particulate matter (PM) is a major component of ambient air pollution. PM exposure is linked to numerous adverse health effects, including chronic lung diseases. Air quality guidelines designed to regulate levels of ambient PM are currently based on the mass concentration of different particle sizes, independent of their origin and chemical composition.
View Article and Find Full Text PDFCharacterising Carbon Monoxide Household Exposure and Health Impacts in High- and Middle-Income Countries-A Rapid Literature Review, 2010-2024.
Int J Environ Res Public Health
January 2025
Environmental Epidemiology Team, Radiation, Chemical and Environmental Hazards Directorate, UK Health Security Agency (UKHSA), Didcot OX11 0RQ, UK.
Carbon monoxide (CO) is a toxic gas, and faulty gas appliances or solid fuel burning with incomplete combustion are possible CO sources in households. Evaluating household CO exposure models and measurement studies is key to understanding where CO exposures may result in adverse health outcomes. This assists the assessment of the burden of disease in high- and middle-income countries and informs public health interventions in higher-risk environments.
View Article and Find Full Text PDFMicroplastics in Agricultural Crops and Their Possible Impact on Farmers' Health: A Review.
Int J Environ Res Public Health
December 2024
Department Innovative Technologies in Medicine and Dentistry, University "G. d'Annunzio", Via dei Vestini, 66100 Chieti, Italy.
The indiscriminate use of plastic products and their inappropriate management and disposal contribute to the increasing presence and accumulation of this material in all environmental zones. The chemical properties of plastics and their resistance to natural degradation lead over time to the production of microplastics (MPs) and nanoplastics, which are dispersed in soil, water, and air and can be absorbed by plants, including those grown for food. In agriculture, MPs can come from many sources (mulch film, tractor tires, compost, fertilizers, and pesticides).
View Article and Find Full Text PDFAn epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish.
Sci Rep
January 2025
Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA.
Human exposure to polycyclic aromatic hydrocarbons (PAH) is a significant public health problem that will worsen with a warming climate and increased large-scale wildfires. Here, we characterize an epigenetic memory at the cytochrome P450 1 A (CYP1A) gene in wild Fundulus heteroclitus that have adapted to chronic, extreme PAH pollution. In wild-type fish, CYP1A is highly induced by PAH.
View Article and Find Full Text PDFIndustrial air emissions and breast cancer incidence in a United States-wide prospective cohort.
Epidemiology
January 2025
Epidemiology Branch, Division of Intramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Background: We evaluated air emissions of industrial compounds, many of which have carcinogenic or endocrine disrupting properties, in relation to breast cancer incidence.
Methods: Using the United States Environmental Protection Agency's Toxics Release Inventory, we quantified air emissions of 28 compounds near Sister Study participants' residences during the 10 years leading up to study enrollment (2003-2006; n=46,150). We used Cox proportional hazards regression to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for associations of residential emission levels of single pollutants with incident breast cancer.
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