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Farnesol as an antifungal agent: comparisons among and haploid and diploid and .
Front Physiol
November 2023
School of Biological Sciences, University of Nebraska, Lincoln, NE, United States.
Farnesol was identified 20 years ago in a search for quorum sensing molecules (QSM), but there is still uncertainty regarding many aspects of its mode of action including whether it employs farnesol transport mechanisms other than diffusion. Based on the structural similarity between farnesol and the farnesylated portion of the pheromone, we explored the effects of ploidy and mating type locus () on the antifungal activity of exogenous farnesol. We approached this question by examining five and five haploid strains with regard to their farnesol sensitivity in comparison to six heterozygous diploids.
View Article and Find Full Text PDFA new dataset of pheromone and pheromone-gene structures from the ciliate, .
Data Brief
August 2023
Laboratory of Eukaryotic Microbiology and Animal Biology, School of Bioscience and Veterinary Medicine, University of Camerino, Italy.
Like many other organisms, ciliates communicate and interact socially via diffusible chemical signals, named pheromones, that are functionally associated with a genetic mating-type mechanism of cell self/not-self recognition. In species, pheromones form species-specific families of small, globular, and disulfide-rich proteins folding into exclusively helical secondary structures. Each is specified by one of a series of high-multiple alleles that are inherited in Mendelian fashion with relationships of co-dominance at the so-called genetic locus of the cell transcriptionally inert micronuclear genome, and expressed in the transcriptionally active macronuclear genome as individual DNA molecules in which the central coding region is flanked by 5'-leader and 3'-trailer noncoding regions ending with CA/TG telomeric repeats.
View Article and Find Full Text PDFRole of the Heme Activator Protein Complex in the Sexual Development of Cryptococcus neoformans.
mSphere
June 2022
Department of Biotechnology, Yonsei University, Seoul, Republic of Korea.
The CCAAT-binding heme activator protein (HAP) complex, comprising the DNA-binding heterotrimeric complex Hap2/3/5 and transcriptional activation subunit HapX, is a key regulator of iron homeostasis, mitochondrial functions, and pathogenicity in Cryptococcus neoformans, which causes fatal meningoencephalitis. However, its role in the development of human fungal pathogens remains unclear. To elucidate the role of the HAP complex in C.
View Article and Find Full Text PDFStudies on male gonadal toxicity of bisphenol A in diabetic rats: An example of exacerbation effect.
J Biochem Mol Toxicol
April 2022
Department of Pharmacology and Toxicology, Facility for Risk Assessment and Intervention Studies, National Institute of Pharmaceutical Education and Research, S.A.S Nagar, Sahibzada Ajit Singh Nagar, Punjab, India.
Bisphenol A (BPA), a widely used organic synthetic chemical alters spermatogenesis and is a potential risk factor for male infertility. Diabetes-induced hyperglycemia has a negative impact on different vital organs including the testis. However, the effect of BPA on male fertility and gonadal development in diabetic (DIA) patients is unknown.
View Article and Find Full Text PDFMorphoproteomics Identifies SIRT1, EZH2 and CXCR4 Pathways in Diffuse Large B-Cell Lymphoma: Therapeutic Implications.
Ann Clin Lab Sci
January 2022
Department of Pathology and Laboratory Medicine, the University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.
Objective: Diffuse large B-cell lymphoma (DLBCL) is the most aggressive form of non-Hodgkin's lymphoma.
Methods: We applied morphoproteomics to a tissue microarray of DLBCL cases to uncover commonalities in its biology with therapeutic implications. Morphoproteomic analysis of 9 individual cases of classic DLBCL included immunohistochemical probes to detect silent mating type information regulation 2 homolog 1 (SIRT1), enhancer of Zeste homolog 2 (EZH2) and C-X-C chemokine receptor 4 (CXCR4) and their cellular compartmentalization by bright field microscopy.
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