Design and synthesis of potent and selective inhibitors of integrin VLA-4.

Bioorg Med Chem Lett

Novartis Institute for Biomedical Research, Novartis Pharmaceuticals Corporation, 556 Morris Avenue, Summit, NJ 07901, USA.

Published: November 2001

The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are also presented.

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http://dx.doi.org/10.1016/s0960-894x(01)00586-8DOI Listing

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