AI Article Synopsis
- Normal male articular cartilage was studied to assess how it responds to somatomedin (SM) activity across different ages.
- The research found that both 3H-thymidine and 35S-sulfate incorporation decreased as age increased, indicating less cellular activity in older cartilage.
- Notably, cartilage from adolescents (ages 12-17) showed the highest enhancement in isotope incorporation when normal plasma was added, suggesting that heightened sensitivity to somatomedins may play a role in increased skeletal growth during this developmental stage.
Article Abstract
Normal male articular cartilage (34 specimens, age range 1--30 years) has been examined in vitro for response to somatomedin (SM) activity. Basal 3H-thymidine and 35S-sulfate incorporation both decreased with increasing age of the cartilage donor. However, enhancement of isotope incorporation which was attained on addition of 10% normal plasma (containing IU SM/ml) was greatest in cartilage from adolescents in the age range 12--17 years. The mean enhancement of 3H-thymidine incorporation (expressed as % basal) was as follows: age 1--10 years = 184 +/- 28 (SE), N = 9; 12--17 years = 436 +/- 101 (11); 18--30 years = 231 +/- 49 (8); and for 35S-sulfate incorporation was 1--10 years = 389 +/- 100 (8); 12--17 years = 824 +/- 273 (11); and 18--30 years = 572 +/- 56 (8). The increased response of cartilage in the 12--17 year group suggests that a greater sensitivity to the somatomedins may contribute to the increased skeletal growth during adolesence.
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| http://dx.doi.org/10.1007/BF02408062 | DOI Listing |
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