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Chemical Composition and Analgesic and Antidiabetic Activity of Chenopodium ambrosioides L.
Cell Biochem Funct
December 2024
Laboratory of Analytical Chemistry and Food Science, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Article Synopsis
- This study investigates the active compounds in Chenopodium ambrosioides for their analgesic and antidiabetic properties, motivated by the plant's therapeutic effects.
- The research utilized gas chromatography-mass spectrometry to analyze various aqueous extracts and fractions, finding several significant chemical families and compounds associated with these properties.
- In the assays, the ethyl acetate fraction (EAF) displayed the highest α-amylase inhibition, while the infused aqueous macerate (EAM) was the most effective against α-glucosidase, outperforming the standard antidiabetic drug acarbose.
Defining Cardiomyocyte Repolarization Response to Pharmacotherapy in Long-QT Syndrome Type 3.
J Am Heart Assoc
October 2024
Regenerative Medicine Institute, School of Medicine University of Galway Galway Ireland.
Article Synopsis
- Long-QT syndrome type 3 (LQT3) is a cardiac ion channel disorder that increases the risk of dangerous heart rhythms, and this study aimed to create a model using human induced pluripotent stem cells (hiPSCs) to better understand the disease and test potential treatments.!
- Researchers generated hiPSCs from a patient with LQT3 and a healthy individual, employing CRISPR/Cas9 to introduce the same genetic mutation into healthy cells; all hiPSC lines were then converted into heart cells for analysis.!
- Both patient-derived and engineered LQT3 heart cells exhibited longer repolarization times, but treatments like mexiletine, nifedipine, and verapamil could effectively alter these
Effects of SZV-2649, a new multiple ion channel inhibitor mexiletine analogue.
Sci Rep
October 2024
Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
The antiarrhythmic and cardiac electrophysiological effects of SZV-2649 that contains a 2,6-diiodophenoxy moiety but lacks the benzofuran ring system present in amiodarone, were studied in mammalian cell line, rat and dog cardiac preparations. SZV-2649 exerted antiarrhythmic effects against coronary artery occlusion/reperfusion induced ventricular arrhythmias in rats and in acetylcholine- and burst stimulation induced atrial fibrillation in dogs. SZV-2649 inhibited hERG and GIRK currents in HEK cells (IC: 342 and 529 nM, respectively).
View Article and Find Full Text PDFBK channels promote action potential repolarization in skeletal muscle but contribute little to myotonia.
Pflugers Arch
November 2024
Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH, 45435, USA.
Patients with myotonia congenita suffer from slowed relaxation of muscle (myotonia), due to hyperexcitability caused by loss-of-function mutations in the ClC-1 chloride channel. A recent study suggested that block of large-conductance voltage- and Ca- activated K channels (BK) may be effective as therapy. The mechanism underlying efficacy was suggested to be lessening of the depolarizing effect of build-up of K in t-tubules of muscle during repetitive firing.
View Article and Find Full Text PDFCharacterization of ClC-1 chloride channels in zebrafish: a new model to study myotonia.
J Physiol
August 2024
Physiology Unit, Department of Physiological Sciences, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona-IDIBELL, Barcelona, Spain.
The function of the chloride channel ClC-1 is crucial for the control of muscle excitability. Thus, reduction of ClC-1 functions by CLCN1 mutations leads to myotonia congenita. Many different animal models have contributed to understanding the myotonia pathophysiology.
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