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Impact of the hydrophilic-lipophilic balance of free-base and Zn(II) tricationic pyridiniumporphyrins and irradiation wavelength in PDT against the melanoma cell lines.
Eur J Med Chem
January 2025
Faculty of Biotechnology and Drug Development, University of Rijeka, Radmile Matejčić 2, Rijeka, Croatia. Electronic address:
The amphiphilic and asymmetric structure of porphyrins, when used as photosensitizers (PSs) for photodynamic therapy (PDT), has been shown through numerous previous studies to be a very important property that facilitates their entry into cells, which improves their efficiency in PDT. In this work, two groups of cationic AB pyridiniumporphyrins, free-base and chelated with Zn(II), both substituted with alkyl chains of various lengths, were studied in PDT on melanoma cell lines. The aim was to investigate the impact of hydrophilic-lipophilic balance and Zn(II) chelation, and the importance of matching the irradiation wavelength to the optical properties of the PS on in vitro PDT efficiency.
View Article and Find Full Text PDFDiels-Alder Reaction Mechanisms of La@C and Gd@C Studied Using Density Functional Theory.
Chemistry
November 2024
Institute of Chemical Research of Catalonia (ICIQ-CERCA), The Barcelona Institute of Science and Technology, Avgda. Països Catalans, 16, Tarragona, 43007, Spain.
Encapsulation of transition metals represents a crucial method for modifying the electronic structure and regulating the reactivity of fullerene, thereby expanding its applications. Herein, we present calculations with density functional theory methods to investigate the mechanisms of the Diels-Alder (DA) reactions of cyclopentadiene and La@C or Gd@C as well as their tricationic derivatives. Our findings indicate that the encapsulation of La and Gd into the C cage is thermodynamically favorable.
View Article and Find Full Text PDFIridium(III)-based minor groove binding complexes as DNA photocleavage agents.
Dalton Trans
April 2024
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK.
Article Synopsis
- New tricationic iridium(III) complexes featuring the qtpy ligand show potential as DNA intercalators and minor groove binders, with good water solubility as chloride salts.
- These complexes exhibit high-energy excited states that are quenched in the presence of duplex DNA and certain mononucleotides like GMP and AMP.
- They preferentially bind to duplex DNA over quadruplex structures and act as synthetic photonucleases capable of cleaving DNA when irradiated with light.
Boron Polycation Supported by Cyclic Bis(carbodiphosphorane).
Chemistry
October 2023
Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
A novel cyclic bis(carbodiphosphorane) ligand was prepared and investigated in coordination with group 13 elements, B, Al, and Ga. Al and Ga afforded dinuclear adduct where two metal centers were bridged by the bis(carbodiphosphorane) ligand. In contrast, the reaction with boron trichloride afforded a monomeric dicationic three-coordinate boron species composed of one boron moieties and one ligand.
View Article and Find Full Text PDFReversible Multielectron Release from Redox-Active Three-Dimensional Molecular Barrels with Ruthenium-Alkenyl Moieties.
Inorg Chem
August 2022
Fachbereich Chemie, Universität Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany.
Three-dimensional molecular barrels and were synthesized in high yields from dinuclear ruthenium-vinyl clamps and tritopic triphenylamine-derived carboxylate linkers and characterized by multinuclear NMR spectroscopy including H-H COSY and H DOSY measurements, high-resolution electrospray ionization mass spectrometry, and X-ray crystallography. The metal frameworks of the cages adopt the shape of twisted trigonal prisms, and they crystallize as racemic mixtures of interdigitating Δ- and Λ-enantiomers with a tight columnar packing in . Electrochemical studies and redox titrations revealed that the cages are able to release up to 11 electrons on the voltammetric timescale and that their cage structures persist up to the hexacation level.
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