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In vivo selection of hepatocytes.
Hepatology
October 2024
Department of Pediatrics, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, Oregon, USA.
The liver is a highly regenerative organ capable of significant proliferation and remodeling during homeostasis and injury responses. Experiments of nature in rare genetic diseases have illustrated that healthy hepatocytes may have a selective advantage, outcompete diseased cells, and result in extensive liver replacement. This observation has given rise to the concept of therapeutic liver repopulation by providing an engineered selective advantage to a subpopulation of beneficial hepatocytes.
View Article and Find Full Text PDFExploring early Acheulian technological decision-making: A controlled experimental approach to raw material selection for percussive artifacts in Melka Wakena, Ethiopia.
PLoS One
January 2025
Department of Prehistory, Institute of Archaeology, Hebrew University of Jerusalem, Jerusalem, Israel.
The evolution of human behaviour is marked by key decision-making processes reflected in technological variability in the early archaeological record. As part of the technological system, differences in raw material quality directly affect the way that humans produce, design and use stone tools. The selection, procurement and use of various raw materials requires decision-making to evaluate multiple factors such as suitability to produce and design tools, but also the materials' efficiency and durability in performing a given task.
View Article and Find Full Text PDFHydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment.
Cell Rep
January 2025
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:
Caenorhabditis elegans proliferates poorly in the presence of abundant Actinobacteria from its natural ecology, but it is unknown why. Here, we show how perturbed levels of hydrogen sulfide modulate the growth rate of both C. elegans and Actinobacteria.
View Article and Find Full Text PDFStackDILI: Enhancing Drug-Induced Liver Injury Prediction through Stacking Strategy with Effective Molecular Representations.
J Chem Inf Model
January 2025
Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 2001 Longxiang Road, 518172 Shenzhen, China.
Drug-induced liver injury (DILI) is a major challenge in drug development, often leading to clinical trial failures and market withdrawals due to liver toxicity. This study presents StackDILI, a computational framework designed to accelerate toxicity assessment by predicting DILI risk. StackDILI integrates multiple molecular descriptors to extract structural and physicochemical features, including the constitution, pharmacophore, MACCS, and E-state descriptors.
View Article and Find Full Text PDFReplicator dynamics on heterogeneous networks.
J Math Biol
January 2025
Laboratory of Mathematics and Complex Systems, Ministry of Education, School of Mathematical Sciences, Beijing Normal University, Beijing, People's Republic of China.
Networked evolutionary game theory is a well-established framework for modeling the evolution of social behavior in structured populations. Most of the existing studies in this field have focused on 2-strategy games on heterogeneous networks or n-strategy games on regular networks. In this paper, we consider n-strategy games on arbitrary networks under the pairwise comparison updating rule.
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