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On the competition of the purine bases, functionalities of peptide side chains, and protecting agents for the coordination sites of dicationic cisplatin derivatives.
J Am Chem Soc
May 2002
Swiss Center for Scientific Computing, SCSC, Swiss Federal Institute of Technology, ETH Zurich, CH-6728 Manno, Switzerland.
The Pt-L bond energies of simple triammineplatinum(II) complexes, [Pt(NH(3))(3)L](2+), with oxygen-, nitrogen-, and sulfur-containing donor ligands L have been predicted and rationalized using density functional theory. The ligands L have been chosen as models for functionalities of peptide side chains, for sulfur-containing protecting agents, and for adenine and guanine sites of the DNA as the ultimate target of platinum anticancer drugs. Calculation of the Pt-L bond energy in [Pt(NH(3))(3)L](2+) reveals that the soft metal center of triammineplatinum(II) prefers N ligands over S ligands.
View Article and Find Full Text PDFTriammineplatinum(II) Coordinated to a Guanine Does Not Prevent Platination of an Adjacent Guanine in Single-Stranded Oligonucleotides.
Inorg Chem
February 1996
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France.
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