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Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians.
PLoS One
January 2025
Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America.
Mental illnesses put a tremendous burden on afflicted individuals and society. Identification of novel drugs to treat such conditions is intrinsically challenging due to the complexity of neuropsychiatric diseases and the need for a systems-level understanding that goes beyond single molecule-target interactions. Thus far, drug discovery approaches focused on target-based in silico or in vitro high-throughput screening (HTS) have had limited success because they cannot capture pathway interactions or predict how a compound will affect the whole organism.
View Article and Find Full Text PDFUse of a Continuum-Based Framework to Advance General Health Integration in Community Behavioral Health Clinics.
Psychiatr Serv
January 2025
Montefiore Care Management Organization, New York City (Smali, Chung); Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York City (Finnerty); Department of Psychiatry and Irving Institute for Clinical and Translational Research, Columbia University, and New York State Psychiatric Institute, New York City (Pincus); Behavioral Health Administration, Maryland Department of Health, Baltimore (Talley); Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle (Goldman); private practice, New York City (Woodlock); Department of Psychiatry, Albert Einstein College of Medicine, New York City (Chung).
Objective: This study assessed the utility and effectiveness of the new general health integration (GHI) framework among community behavioral health organizations designated as certified community behavioral health clinics (CCBHCs) or in the process of applying to become a CCBHC.
Methods: Nineteen licensed community behavioral health clinics, 18 of which had CCBHC status, participated in a 12-month learning collaborative. They used the GHI framework to assess their integration stage for 15 subdomains within eight domains of evidence-based practice.
Effects of an Organizational Implementation Strategy on Sustainment of Measurement-Based Care in Community Mental Health.
Psychiatr Serv
January 2025
School of Social Work, Boise State University, Boise, Idaho (Williams, Esp); Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla (Aarons, Sklar, Carandang, Brookman-Frazee); Department of Psychology, University of Central Florida, Orlando (Ehrhart); Ballmer Institute for Children's Behavioral Health, University of Oregon, Portland (Vega); School of Social Policy and Practice, University of Pennsylvania, Philadelphia (Marcus).
Objective: Little is known about how to sustain evidence-based interventions with fidelity in community mental health settings. Phase 1 of the Working to Implement and Sustain Digital Outcome Measures (WISDOM) trial showed that an organizational strategy improved the implementation of measurement-based care (MBC) in mental health services for youths 1-12 months after clinician MBC training. The authors report results from phase 2 of the trial, in which the strategy's effects on MBC sustainment 13-26 months after clinician MBC training were examined.
View Article and Find Full Text PDFEmotional ecosystems: Understanding the relationship between family interactions and anxiety among cancer caregivers.
Palliat Support Care
January 2025
Washington University in St. Louis School of Medicine, Saint Louis, MO, USA.
Objectives: Recent studies have challenged the assumption that families are invariable sources of support for cancer caregivers, noting that relationships with family members can have both positive and negative effects on caregiver well-being. This study expands upon prior literature to examine the relationship between cancer caregivers' perceptions of the quality of their family interactions and their symptoms of anxiety.
Methods: We employed secondary analysis of baseline data from a multisite randomized clinical trial of an intervention for cancer caregivers conducted at 3 large academic palliative care clinics.
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