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Perioperative Aspirin Use Is Associated with Bleeding Complications during Robotic Partial Nephrectomy.
J Urol
February 2022
Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Article Synopsis
- Daily aspirin (pASA) use after cardiovascular interventions is common but raises concerns about bleeding risks during surgery, leading many to stop taking it before major procedures.
- A multicenter study analyzed 1,565 patients undergoing robotic partial nephrectomy (RPN), comparing outcomes of those on pASA (81 mg) to those not using it.
- The study found that while pASA use was associated with an increased risk of blood transfusions (11% vs 4%) and major complications (10% vs 3%), it may still be safe when performed by experienced surgeons, suggesting a need for further research on its role in such surgeries.
Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK.
Br J Psychiatry
January 2006
Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK.
Background: Brain-derived neurotrophic factor (BDNF) influences neuronal survival, proliferation and plasticity. Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder.
Aims: To replicate this finding.
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