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Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood-Testis Barrier in Mice.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Reproductive Medicine and Offspring Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Perfluorohexane sulfonic acid (PFHxS) is extensively used in waterproof coatings and fire-fighting foams, and several studies have found it to be a potential health hazard, but there is still unknown about its effects on spermatogenesis. Our results showed that PFHxS-treated mice have significant reproductive toxicity, including a decrease in sperm count and motility, and the levels of sex hormones (P < 0.05).
View Article and Find Full Text PDFA machine learning based variable selection algorithm for binary classification of perinatal mortality.
PLoS One
January 2025
Department of Statistics, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
The identification of significant predictors with higher model performance is the key objective in classification domain. A machine learning-based variable selection technique termed as CARS-Logistic model is proposed by coupling competitive adaptive re-weighted sampling(CARS) and logistic regression for binary classification. Based on five assessment criteria, the proposed method is found to be more efficient than Forward selection logistic regression model.
View Article and Find Full Text PDFLow maternal iodine intake and subsequent risk of pharmacologically treated hypertension: A population-based prospective cohort study.
Clin Nutr
January 2025
Department of Food Safety, Centre of Sustainable Diets, Norwegian Institute of Public Health, P.O. Box 222, NO-0213 Oslo, Norway. Electronic address:
Background & Aims: Iodine deficiency is linked to multiple adverse health outcomes, but there is scarce knowledge regarding iodine intake and development of chronic hypertension. We aimed to investigate the prospective association between habitual dietary iodine intake and pharmacologically treated hypertension in mothers up to 10 years after delivery.
Methods: The present study is based on data from an ongoing pregnancy cohort and includes 58,629 women without thyroid dysfunction and hypertension at baseline.
Tire rubber-derived contaminants 6PPD and 6PPD-quinone reduce attachment and outgrowth of trophoblast spheroids onto endometrial epithelial cells.
Ecotoxicol Environ Saf
January 2025
Korea Institute of Toxicology, Daejeon 34114, Republic of Korea. Electronic address:
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), a synthetic additive widely used in the rubber industry, and its oxidized product 6PPD-quinone (6PPDQ), have garnered widespread attention as an emerging hazardous chemicals owing to their potential detrimental effects on aquatic ecosystem and human health. The effects of 6PPD and 6PPDq on the female reproductive tract, especially embryo implantation, remain unknown and were investigated in this study. We used the spheroid attachment and outgrowth models of BeWo trophoblastic spheroids and Ishikawa cells as surrogates for the human blastocyst and endometrial epithelium, respectively.
View Article and Find Full Text PDFCooperation of Lactoplantibacillus plantarum and polyethylene microplastics facilitated the disappearance of tetracycline during anaerobic fermentation of whole plant maize.
J Hazard Mater
January 2025
College of Animal Science, Guizhou University, Guiyang 550025, China; Key Laboratory of Animal Genetics, Breeding & Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang 550025, China. Electronic address:
In agricultural production systems, the harm of both antibiotics and microplastics (MPs) to human health has been an important and continuously concerned issue. A small bagged silage production system was designed to investigate the effects of Lactoplantibacillus plantarum, polyethylene (PE) -MPs and their mixture on the silage fermentation and chemical composition of Tetracycline (TET) -contaminated whole plant maize. In addition, the bacterial community of silage samples was analyzed by using next generation genome sequencing technology.
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