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Intrinsic Breakdown Strength: Theoretical Derivation and First-Principles Calculations.
Phys Rev Lett
February 2025
Fudan University, Key Laboratory of Computational Physical Sciences (Ministry of Education), Institute of Computational Physical Sciences, and Department of Physics, Shanghai 200433, China.
Intrinsic breakdown strength (F_{bd}), as the theoretical upper limit of electric field strength that a material can sustain, plays important roles in determining dielectric and safety performance. The well accepted concept is that a larger band gap (E_{g}) often leads to a larger intrinsic breakdown strength. In this work, we analytically derive a simplified model of F_{bd}, showing a linear relationship between F_{bd} and the maximum electron density of states (DOS_{max}) within the energy range spanning from the conduction band minimum (CBM) to CBM+E_{g}.
View Article and Find Full Text PDFUncovering the Fluctuation of Peroxynitrite during Early Embryonic Development Using an Integrative Nanobeacon.
Anal Chem
March 2025
Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Pharmaceutical Engineering, Changsha University of Science and Technology, Changsha 410114, PR China.
Embryonic development is the beginning of life, and various kinds of bioactive molecules are implicated in this crucial process. Especially in its early stage, some important biochemical reactions regulating physiological balance may be resuscitated. Thus, revealing the dynamic changes of bioactive molecules during early embryonic development is crucial to the elucidation of biological phenomena.
View Article and Find Full Text PDFFronthaul plays a crucial role in bridging mobile and optical communications. Conventional digital radio-over-fiber (RoF) systems, utilizing the common public radio interface (CPRI), require a capacity exceeding an order of magnitude above the user data rate, posing challenges for dense small cell deployments and the growing bandwidth demands of 6 G and beyond. Intermediate-frequency-over-fiber (IFoF) with intensity modulation and direct detection (IM/DD) presents a promising alternative due to its high spectral efficiency and simpler architecture.
View Article and Find Full Text PDFA targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy.
Oncoimmunology
December 2025
School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Targeted therapies leveraging the innate immune system are emerging as promising cancer treatments. The mitochondrial antiviral signaling protein (MAVS) plays a crucial role in initiating innate immune responses, but its clinical use is limited by the risk of uncontrolled activation and systemic toxicity. To address this, we developed a novel therapeutic agent, the truncated interferon activation switch (TRIAS), combining MAVS truncates with a tumor antigen-targeting single-chain variable fragment (scFv).
View Article and Find Full Text PDFImpact of Head and Neck Posture on Swallowing Kinematics and Muscle Activation: A Systematic Review.
Dysphagia
March 2025
Fonoaudiología. Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, Chile.
Swallowing is a complex neuromuscular process involving the coordination of anatomical structures in the central and peripheral nervous systems. The posture of the head and neck plays a critical role in the biomechanics of swallowing, especially in populations with dysphagia. This systematic review aims to explore the impact of head-neck posture on swallowing kinematics and muscle activation, providing a multidisciplinary perspective for optimizing dysphagia management.
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