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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2.
Biomolecules
January 2025
Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University, 00185 Rome, Italy.
Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of cellular homeostasis, overseeing the expression of a wide array of genes involved in cytoprotective processes such as antioxidant and proteostasis control, mitochondrial function, inflammation, and the metabolism of lipids and glucose. The accumulation of misfolded proteins triggers the release, stabilization, and nuclear translocation of NRF2, which in turn enhances the expression of critical components of both the proteasomal and lysosomal degradation pathways. This process facilitates the clearance of toxic protein aggregates, thereby actively maintaining cellular proteostasis.
View Article and Find Full Text PDFKey considerations for combination therapy in Alzheimer's clinical trials: Perspectives from an expert advisory board convened by the Alzheimer's drug discovery foundation.
J Prev Alzheimers Dis
January 2025
Alzheimer's Drug Discovery Foundation, New York, NY, USA. Electronic address:
There is growing consensus in the Alzheimer's community that combination therapy will be needed to maximize therapeutic benefits through the course of the disease. However, combination therapy raises complex questions and decisions for study sponsors, from preclinical research through clinical trial design to regulatory, statistical, and operational considerations. In January 2024, the Alzheimer's Drug Discovery Foundation convened an expert advisory board to discuss the key considerations in each of these areas.
View Article and Find Full Text PDFPolicy coherence of price controls on food and noncommunicable disease prevention, WHO South-East Asia and Western Pacific regions.
Bull World Health Organ
January 2025
Institute for Health Transformation, Deakin University, Barwon Heads, Australia.
Noncommunicable diseases are the leading cause of death and disability globally, with suboptimal diet being a significant risk factor. Fiscal policies that promote nutritious foods have been identified as part of a best-practice package of interventions and are a focus for governments in the current context of rising food prices. Price controls are a strategy that governments commonly apply to limit mark-up on prices of specific foods, with the aim of protecting consumers and promoting food security.
View Article and Find Full Text PDFL-Arginine supplementation as mitochondrial therapy in diabetic cardiomyopathy.
Cardiovasc Diabetol
December 2024
Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
In patients with type II diabetes, the development of diabetic cardiomyopathy (DC) is associated with a high risk of mortality. Left ventricular hypertrophy, diastolic dysfunction, and exercise intolerance are the first signs of DC. The underlying mechanisms are not fully elucidated, and there is an urgent need for specific biomarkers and molecular targets for early diagnosis and treatment.
View Article and Find Full Text PDF[The role of regulatory agencies within health systems during emergencies in BrazilPapel de los organismos regulatorios en los sistemas de salud en situaciones de emergencia en Brasil].
Rev Panam Salud Publica
December 2024
Escola Nacional de Saúde Pública Sergio Arouca Fundação Oswaldo Cruz. Rio de Janeiro-RJ Brasil Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz. Rio de Janeiro-RJ, Brasil.
Article Synopsis
- The performance of health systems relies on ensuring the right to health and is influenced by state regulatory actions aimed at reducing health risks and promoting equity.
- Regulatory agencies, particularly in Brazil (e.g., ANVISA), have adapted their practices during public health emergencies (PHEs) to enhance health system resilience, focusing on quick access to safe products, quality of care, and public communication.
- Improved response capacities, such as the expedited approval of COVID-19 vaccines and collaboration among agencies, highlight the importance of regulatory efforts in strengthening health systems and addressing challenges like misinformation.
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