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The Different Paths That Lead to Hypotonic Hyponatremia, and a Safe Approach to Treatment.
J Clin Med
December 2024
NYU Grossman Long Island School of Medicine, 101 Mineola Blvd., Mineola, NY 11501, USA.
A knowledge gap may exist when attempting to identify the pathogenetic mechanisms resulting in the syndrome of inappropriate antidiuretic hormone (SIADH) or hypotonic hyponatremia. Ectopic secretion of antidiuretic hormone [ADH] is the classic cause of SIADH. But another form of inappropriate secretion of ADH occurs when interleukin 6 is activated.
View Article and Find Full Text PDFMolecular substratification of endometrial carcinomas with no special molecular profile (NSMP) by using a limited NGS custom panel may facilitate effective patient selection for the PIK3CA-targeted therapy.
Virchows Arch
September 2024
Department of Pathology, Medical Faculty in Pilsen, Charles University, Prague, Czech Republic.
Endometrial carcinomas (EC) of no special molecular profile (NSMP) represent the largest molecular category of EC, comprising a mixture of tumors with different histology and molecular profiles. These facts likely point to different tumor biology, clinical outcomes, and targeted therapy responses within this molecular category. The PIK3CA is currently the only targetable kinase oncoprotein directly implicated in EC carcinogenesis.
View Article and Find Full Text PDFThe Current Understanding of Molecular Mechanisms in Adenomyosis-Associated Infertility and the Treatment Strategy for Assisted Reproductive Technology.
Int J Mol Sci
August 2024
Department of Obstetrics and Gynecology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Article Synopsis
- Adenomyosis, a condition affecting the uterus, impairs fertility by disrupting the normal processes important for embryo implantation and development, influenced by various hormones and inflammatory factors.
- Current research indicates that adenomyosis is linked to lower pregnancy rates, higher miscarriage rates, and poor outcomes for both mothers and newborns.
- Treatment options, including medications and surgery, show promise in enhancing reproductive outcomes, especially when using GnRHa protocols, which can improve implantation rates and assist with natural conception efforts.
[Epilepsy with PCDH19 mutation: polypharmacy as a consequence of the complexity and diversity of pathogenesis mechanisms].
Zh Nevrol Psikhiatr Im S S Korsakova
August 2024
Russian Medical Academy of Continuous Professional Education, Moscow, Russia.
Mutations in the human gene lead to epileptic encephalopathy of early childhood. It is characterized by the early onset of serial seizures, cognitive impairment and behavioral disorders (including autistic personality traits). In most cases, difficulties arise in selecting therapy due to pharmacoresistance.
View Article and Find Full Text PDFMitochondrial structural alterations in fibromyalgia: a pilot electron microscopy study.
Clin Exp Rheumatol
June 2024
Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Objectives: The pathogenesis of fibromyalgia (FM), characterised by chronic widespread pain and fatigue, remains notoriously elusive, hampering attempts to develop disease modifying treatments. Mitochondria are the headquarters of cellular energy metabolism, and their malfunction has been proposed to contribute to both FM and chronic fatigue. Thus, the aim of the current pilot study, was to detect structural changes in mitochondria of peripheral blood mononuclear cells (PBMCs) of FM patients, using transmission electron microscopy (TEM).
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