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A Collaborative Stakeholder Approach for Reducing the Use of Custodial Restraints in Hospitalized Patients.
J Correct Health Care
January 2025
The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
In hospitals across the country, most patients admitted from jails or prisons receive their care in custodial restraints regardless of clinical concerns or public safety risk. Blanket restraint protocols are deemed necessary for public safety; however, the indiscriminate use of custodial restraints causes harm to patients physically, mentally, and through propagation of prejudice. Hospitals and correctional officials must create policies that allow for a case-by-case analysis of patients to develop an individualized custodial restraint plan that will balance public safety and patient care needs.
View Article and Find Full Text PDFEffects of a Distributed Form of Constraint-Induced Movement Therapy for Clinical Application: The Keys Treatment Protocol.
Brain Sci
January 2025
Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Background/aim: Currently, there are limited evidence-based protocols for improving upper extremity (UE) motor function after stroke. The Keys protocol, a distributed form of constraint-induced movement therapy (CIMT), delivers CIMT components in fewer hours per day over an extended period, fitting outpatient rehabilitation schedules and third-party payor models. This pilot study aimed to assess the effectiveness of the Keys protocol in enhancing UE capacity and performance poststroke.
View Article and Find Full Text PDFCross-sectional survey of healthcare professionals' perceptions of bedrails as a measure of physical restraint in the hospital setting.
Age Ageing
January 2025
Department of Geriatrics, Consorci Sanitari Alt Penedès-Garraf, Sant Pere de Ribes, Barcelona, Spain.
Objective: Although bedrails are considered a restraint measure under the legal regulations in Spain, no data on the related perceptions of healthcare professionals (HCPs) are available. Thus, this study aimed to calculate the proportion of HCPs in the hospital setting that consider bedrails to be a restraint measure.
Methods: Between June and December 2022, a cross-sectional online survey was conducted among the HCPs at our institution.
Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent mA regulation.
Cell Mol Life Sci
January 2025
The Key Laboratory of Aerospace Medicine, Ministry of Education, Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Disuse bone loss is prone to occur in individuals who lack mechanical stimulation due to prolonged spaceflight or extended bed rest, rendering them susceptible to fractures and placing an enormous burden on social care; nevertheless, the underlying molecular mechanisms of bone loss caused by mechanical unloading have not been fully elucidated. Numerous studies have focused on the epigenetic regulation of disuse bone loss; yet limited research has been conducted on the impact of RNA modification bone formation in response to mechanical unloading conditions. In this study, we discovered that mA reader IGF2BP1 was downregulated in both osteoblasts treated with 2D clinostat and bone tissue in HLU mice.
View Article and Find Full Text PDFChronic restraint stress affects the diurnal rhythms of gut microbial composition and metabolism in a mouse model of depression.
BMC Microbiol
January 2025
Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Background: Depression is a common mental disorder accompanied by gut microbiota dysbiosis, which disturbs the metabolism of the host. While diurnal oscillation of the intestinal microbiota is involved in regulating host metabolism, the characteristics of the intestinal microbial circadian rhythm in depression remain unknown. Our aim was to investigate the microbial circadian oscillation signature and related metabolic pathways in a mouse model with depression-like behaviours.
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