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Does a Specific Sequential Combination of Antiseptic Solutions for Chemical Debridement in Periprosthetic Joint Infection Improve Outcomes vs. Solution Alone? An In Vivo Study.
Antibiotics (Basel)
December 2024
Department of Orthopaedic Surgery and Traumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
: Chemical debridement is a fundamental step during the surgical treatment of both acute and chronic periprosthetic joint infection (PJI). However, there is no consensus on the optimal solution, nor is there sufficient evidence on the optimal irrigation time and combination of solutions. In an in vitro study, our group recently demonstrated that sequential combination debridement (SCD) with 3% acetic acid (AA) followed by 10% povidone iodine (PI) and 5 mM hydrogen peroxide (HO) was the best strategy for reducing bacterial load.
View Article and Find Full Text PDFEffect of intramuscular treatment with different iron dextran dosages and non-inferiority study to gleptoferron.
Acta Vet Scand
January 2025
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 2, 1870, Frederiksberg C, Denmark.
Background: Prevention of iron deficiency in suckling piglets by intramuscular injection of a standardized amount of iron dextran or gleptoferron in the first days of life can lead to over- or underdosage with respective health risks. Currently, combined iron products containing an active substance against coccidia are also used on farms. When using a combination product targeting two diseases, an adjustment of the necessary amount of iron to prevent anaemia in the frame of a farm-specific treatment protocol is not possible.
View Article and Find Full Text PDFMeningeal null cell lymphoma causing diffuse pachymeningeal contrast enhancement in a dog.
J Small Anim Pract
December 2024
Hospital Veterinaria del Mar, IVC Evidensia, Barcelona, Spain.
Article Synopsis
- Diffuse pachymeningeal contrast enhancement in dogs is rare and not well understood in veterinary medicine.
- A 2-year-old neutered female Pug exhibited severe neurological symptoms and MRI revealed thickening and enhancement of the meninges.
- Despite initial treatment showing temporary improvement, the dog relapsed multiple times, leading to euthanasia, where histopathological analysis indicated a rare case of meningeal null cell lymphoma.
[Euthanasia: a mixed-methods study on referents' experience in Catalonia].
Gac Sanit
December 2024
Centro de Atención Primaria Santa Eugènia de Berga, Barcelona, España; Comisión de Garantía y Evaluación de Catalunya (CGAC), España.
Objective: To identify strengths and challenges in the provision of assistance in dying (PAM) based on the experiences of the Catalan Health Institute (ICS) euthanasia referents.
Method: Mixed-methods study (n=31), using two closed-ended questionnaires (quantitative analysis) and two structured interviews with open-ended fields (qualitative analysis), self-administered via email. All ICS referents (n=50) received them.
The influence of a human macronutrient-matched diet on phenotypes in old mice.
Geroscience
November 2024
University of Colorado Boulder, Boulder, CO, USA.
Preclinical rodent models are essential research tools for improving understanding of physiological aging processes in humans. However, the translatability of findings obtained leveraging rodent models to humans is limited, likely due in part to differences in macronutrient composition of the diets. Here, we investigated the impact of a 3-month diet intervention in old male C57BL/6JN mice in which the macronutrient composition was aligned with that of a midlife/older adult in the United States, compared to a traditional rodent diet, and assessed various phenotypes that are typically altered with aging.
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