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Maintenance therapy for chronic lymphocytic leukaemia.
Cochrane Database Syst Rev
January 2024
Division of Hematology and Oncology Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Background: Chronic lymphocytic leukaemia (CLL) is the most common lymphoproliferative disease in adults and currently remains incurable. As the progression-free period shortens after each successive treatment, strategies such as maintenance therapy are needed to improve the degree and duration of response to previous therapies. Monoclonal antibodies, immunomodulatory agents, and targeted therapies are among the available options for maintenance therapy.
View Article and Find Full Text PDFImmune synergistic mechanism of recombinant plasmid adjuvant containing chicken IL-4 and IL-2 fusion genes on chicken coccidia live vaccine.
Poult Sci
January 2024
College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China. Electronic address:
Article Synopsis
- * In a study, chickens were divided into three groups (control, vaccine + adjuvant, and vaccine-only) to assess immune responses and the results showed significant increases in immune markers and lymphocyte populations in the group receiving the adjuvant.
- * Overall, the adjuvant enhanced the immune response by upregulating key cytokines (IL-2, IL-4, TNF-α, IFN-γ) and promoting cell
Clinical Research in Chronic Lymphocytic Leukemia in Pakistan; A Systematic Review.
Medicina (Kaunas)
August 2023
Hematology/ Oncology, Cleveland Clinic, Cleveland, OH 44195, USA.
: Significant advances have been made in the treatment of chronic lymphocytic leukemia (CLL) since the turn of the new millennium. However, most clinical trials were done in developed countries where minority ethnicities were underrepresented. : To gauge the quality of research in CLL being done in Pakistan, we conducted a comprehensive literature search using PubMed, Clinicaltrials.
View Article and Find Full Text PDFClinical Presentation and Prognosis.
Adv Exp Med Biol
July 2023
Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Article Synopsis
- Over the last 30 years, care for meningioma patients has improved due to advancements in understanding the tumors' biology, history, and classification, leading to better management options and outcomes.
- The growing body of research has enhanced our knowledge of molecular factors, paving the way for personalized treatment strategies for patients.
- There is a shift towards more patient-centered measures in evaluating treatment outcomes, recognizing the significant impact even mild symptoms of meningiomas can have on a patient’s quality of life.
Objective To evaluate the cytological changes of the oral mucosa among smokers using Argyrophilic nucleolar organizer region (AgNOR) counts and Papanicolaou (Pap) staining. Methodology The oral mucosal exfoliate smears of 500 individuals (200 nonsmokers and 300 smokers) aged between 18 and 80 years were prepared in Al Madinah. The AgNOR count and Pap stain were used to generate a cytogenic smear to assess the presence of cytological changes suggestive of atypia, inflammation, dysplasia, keratinization, and proliferative activity of epithelial cells.
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