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Epidemiology of metabolic syndrome.
Pflugers Arch
January 2025
Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
The global increase of overweight and obesity in children and adults is one of the most prominent public health threats, often accompanied by insulin resistance, hypertension, and dyslipidemia. The simultaneous occurrence of these health problems is referred to as metabolic syndrome. Various criteria have been proposed to define this syndrome, but no general consensus on the specific markers and the respective cut-offs has been achieved yet.
View Article and Find Full Text PDFArtificial intelligence in healthcare: transforming patient safety with intelligent systems-A systematic review.
Front Med (Lausanne)
January 2025
Department of Law, Institute of Legal Medicine, University of Macerata, Macerata, Italy.
Introduction: Adverse events in hospitals significantly compromise patient safety and trust in healthcare systems, with medical errors being a leading cause of death globally. Despite efforts to reduce these errors, reporting remains low, and effective system changes are rare. This systematic review explores the potential of artificial intelligence (AI) in clinical risk management.
View Article and Find Full Text PDFPharmacy students' opinion on mandatory summer internships carried out in community and hospital pharmacies.
BMC Med Educ
January 2025
Department of Humanities and Social Medicine, Medical University of Lublin, Lublin, Poland.
Background: Pharmacy internships are an important part of pharmacy education in Poland; they are an integral part of professional studies. The first two internships are held after the third and fourth year of study during the summer break and last for four weeks. The study aims to analyze the didactic process of the pharmacy students taking place during the summer internship in community and hospital pharmacies in Poland.
View Article and Find Full Text PDFOver a decade of HIV infection prevalence and incidence among Mozambican pregnant women: a secondary analysis of prospectively collected data.
BMC Public Health
January 2025
Centro de Investigação Em Saúde de Manhiça (CISM), Rua 12, Maputo, Vila da Manhiça, PO Box 1929, Mozambique.
Background: Monitoring HIV infection estimates is critical to guide health interventions and assess their impact, especially in highly vulnerable groups to the infection such as African pregnant women. This study describes the trends of HIV infection over eleven years in women attending selected antenatal care (ANC) clinics from southern Mozambique.
Methods: We performed a secondary analysis of data registered at the ANC clinic of the Manhiça District Hospital and from the Ministry of Health's HIV National Program Registry between 2010 and 2021.
Inhibition of the anti-apoptotic protein BCL2 in EML4-ALK cell models as a second proposed therapeutic target for non-small cell lung cancer.
PLoS One
January 2025
Department of Basic Sciences, Bioethics and Human Life, Faculty of Human Medicine, University of Piura, Miraflores, Lima, Perú.
The anaplastic lymphoma kinase (ALK) oncoprotein plays a crucial role in non-small cell lung cancer (NSCLC) by activating signaling pathways involved in cell proliferation and survival through constitutive phosphorylation. While first-line crizotinib can regulate phosphorylation, mutations in the ALK gene can lead to resistance against ALK inhibitors (ALKi) such as ceritinib and alectinib. On the other hand, overexpression of BCL2, a protein involved in cell death regulation, has been observed in NSCLC and is considered a potential therapeutic target.
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